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SARS-CoV-2 - Dynamics of the COVID-19 Epidemic

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Assistant Professor of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
    Biography

      Harm van Bakel, PhD, is an Assistant Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai (ISMMS) and co-director of the Mount Sinai Health System Pathogen Surveillance Program. His research interests are focused on applying novel genomics technologies to fundamental problems in infectious disease to understand pathogen-host interactions and the molecular basis of evolution and transmission of viruses and bacteria, to ultimately provide insights into new treatment options and approaches to prevent the spread of infectious diseases.


    Abstract

    The global pandemic of Coronavirus disease 2019 (COVID-19), caused by Severe Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has highlighted the importance of surveillance efforts to closely monitor the transmission and evolution of viral pathogens. I will present how the Mount Sinai Health System Pathogen Surveillance Program has applied high-throughput sequencing of SARS-CoV-2 genomes from COVID-19 patients, in combination with molecular epidemiology, to identify the timing and origins of early introductions of SARS-CoV-2 in the New York City metropolitan area and its continued spread. NYC was one of the first affected large cities in the world and an early epicenter of the pandemic. I will further outline how genomic technologies can be applied to precisely delineate outbreaks in quarantine and healthcare settings.

    Learning objectives:

    1. Understand how we can use next-generation sequencing to track the spread and diversity of SARS-CoV-2

    2. Understand how limitations in testing obscured our view of early viral introductions 

    3. Identify and evaluate the contribution of asymptomatic carriers in the transmission of SARS-CoV-2


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