MENU

SARS-CoV-2 Interactions with the Host Innate Immune Response and the Ubiquitin System

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor, Department of Medicine, Director, Center for Virus-Host-Innate Immunity (CVHII), Institute for Infectious and Inflammatory Diseases, Rutgers University, New Jersey Medical School Cancer Center
    BIOGRAPHY

Abstract

The host antiviral innate immune response protects the host against infection. Like with other viruses, the host recognizes SARS-CoV-2 infection and triggers a series of signaling cascades that culminate in the production of cytokines and type-I Interferons (IFN-I) that reduce virus spread. To avoid detrimental inflammation, the IFN system is regulated by different molecular processes, including the host ubiquitin system. However, like other viruses, SARS-CoV-2 has developed mechanisms to antagonize both IFN induction and signaling. In this talk we will discuss mechanisms used by SARS-CoV-2 to escape the innate antiviral response, with a focus on interactions with the host ubiquitin system.
 
Learning objectives:
1. Clarify molecular mechanisms of host innate antiviral immunity that lead to protection against SARS-CoV-2 infection
2. Classify mechanisms of SARS-CoV-2 antagonism of innate immunity and type-I IFN induction
3. Outline mechanisms of virus-host interactions regulated by the host ubiquitin system


Show Resources
You May Also Like
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
JUN 28, 2022 7:00 AM PDT
JUN 28, 2022 7:00 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
NOV 09, 2022 8:00 AM PST
C.E. CREDITS
NOV 09, 2022 8:00 AM PST
Date: November 09, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) The field of cell and gene therapy is rapidly growing. In particular, the use of lentiviruses in CAR-T applications is...
SEP 22, 2022 9:00 AM PDT
SEP 22, 2022 9:00 AM PDT
Date: September 22, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarke...
OCT 13, 2022 9:00 AM +08
OCT 13, 2022 9:00 AM +08
First Broadcast: Date: October 12, 2022 Time: 8:00am PDT, 11:00am EDT Second Broadcast: Date: October 12, 2022 Time: 9:00am SGT The new Embedded CryoSPARC Live, now fully integrated with t...
Loading Comments...
Show Resources