NOV 09, 2017 10:30 AM PST

The Need for Serum 25-hydroxyvitamin D Standardization in Clinical and Research Laboratories

Speaker
  • Coordinator, Vitamin D Standardization Program (VDSP), NIH Office of Dietary Supplements
    Biography
      Christopher T. Sempos, Ph.D., a Nutritional Epidemiologist and Program Director for the Population Studies Program in the NIH Office of Dietary Supplements (ODS) since 2008, retired in July 2015 after more than 27 years of federal government service. Dr. Sempos is now a part-time consultant with ODS who is continuing to serve as coordinator of the Vitamin D Standardization Program (VDSP). VDSP is an international collaborative effort to standardize the laboratory measurement of vitamin D status.

      Dr. Sempos's research areas are in nutritional epidemiology, especially cardiovascular and alcohol epidemiology, nutrition monitoring and public health surveillance methods, dietary survey methods, and biostatistics. Since coming to ODS, his research has focused serum 25-hydroxyvitamin D. The author of more than 100 professional and technical papers, he is also the co-author of the textbook,Statistical Methods in Epidemiology. His work has included numerous papers using data from NHANES including research on iron as a risk factor for heart disease, and national trends in diet and biomarkers of diet.

      Dr. Sempos received his Ph.D. in Nutritional Sciences from the University of Wisconsin-Madison in 1982. At the same time he earned an M.S. in Preventive Medicine-Epidemiology. He completed an NIH postdoctoral fellowship in Biostatistics, Nutrition, Preventive Cardiology and Cardiovascular Epidemiology at the Northwestern University Medical School, Department of Community Health and Preventive Medicine in Chicago, IL, and a postdoctoral fellowship with the U.S. Food and Drug Administration (FDA). From 1999-2004, he was Professor of Epidemiology and Director of Graduate Studies in the Department of Social and Preventive Medicine, University of Buffalo. He also worked in several positions within the Public Health Service from 1983-1999, most notably as Chief, Longitudinal Studies for the Division of Health and Nutrition Examination Surveys (DHANES) at the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention (CDC).

    Abstract

    This webinar builds and expands on the recent labroots webinar by Dr. Gary Horowitz to emphasize how relatively in expensive assay standardization procedures can be incorporated into clinical and research laboratories.  Serum 25-hydroxyvitamin D [25(OH)D] is a very difficult metabolite to measure.   Assay variation continues to confound the clinical assessment of vitamin D deficiency. The Vitamin D Standardization Program (VDSP) was founded in 2010 by the NIH Office of Dietary Supplements in collaboration with organization and researchers around the world to promote the standardized laboratory measurement of 25(OH)D.  In this webinar, we will discuss the (1) meaning of assay standardization, (2) VDSP Reference Measurement System; (3) Cost-effective Steps to Standardize 25(OH)D Measurement; (4) VDSP Performance Guidelines – A Weakness; and (5) Emerging vitamin D standardization issues.


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