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Sex, Gender, the Aging Lung: Epigenetic Findings in COPD

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor of Medicine, Harvard Medical School, Associate Physician, Brigham and Women's Hospital, Department of Medicine
    Biography

      Dawn L. DeMeo, MD, MPH is a Respiratory Epidemiologist at the Channing Division of Network Medicine and a trained Pulmonary/Critical Care Physician; she is an Associate Physician in the Department of Medicine at Brigham and Women’s Hospital and an Associate Professor of Medicine at Harvard Medical School. Her primary research interest is genetics and epigenetics as they relate to lung health, lung disease and intersections with sex, gender and aging. To pursue her interest in understanding COPD susceptibility, including the role of genetics and epigenetics in early-onset COPD and sex differences, she has been the recipient of grants from the National Institutes of Health, the American Lung Association and the Alpha 1 Foundation. Dr. DeMeo’s vision includes streamlining effective multidisciplinary care for lung diseases through careful scientific investigations, with an eventual goal of designing and implementing genomic insights into diagnostics, therapeutics, and preventative strategies for COPD, informed by “Big Data” and Network Medicine approaches inclusive of age, sex and gender aware approaches.


    Abstract

    Sex and gender differences are apparent in health and disease and aduring aging. Chronic obstructive pulmonary disease is a leading cause of death with pronounced sex and gender differences associated with disease susceptibility and severity. Studying genetics and (epi)genomics will allow the development of holistic approaches to modeling the molecular differences that may be further exacerbated for COPD as a disease of accelerated aging. The hope is that big data and sex and gender aware systems and network medicine approaches will inform innovations for diagnostic, therapeutic and preventative approaches to COPD as a disease of aging.

    Learning Objectives:

    1. Overview associations with sex/ gender and lung disease

    2. Note a role for the (epi)genome in sex differeneccs in the lung

    3. Propose a role for Networks to integrate sex and gender differences in understanding COPD


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