Postdoctoral researcher, HHMI research associate, Departments of Bioengineering and Applied Physics, Stanford University
BIOGRAPHY
AUG 21, 2014 9:45 AM PDT
Share
Shotgun sequencing enables non-invasive monitoring of infection and rejection in transplantation
Presented at:
Genetics and Genomics
Speaker
Abstract
Accurate and timely diagnosis of rejection and infection is essential for long-term survival of solid-organ transplant recipients. We evaluated the performance a novel test to monitor rejection and infection through shotgun sequencing of plasma-derived cell-free DNA. We show that an elevated level of donor-derived cell-free DNA correlates with indicators of graft dysfunction and rejection in heart and lung transplantation. We also find a strong correlation between clinical test results and cell-free DNA derived from cytomegalovirus (CMV), the primary infectious disease complication for transplant recipients. We further show that cell-DNA can be used to detect and monitor pathogens that are not routinely screened in the clinic and we show that the composition of viral sequences is highly dynamic and strongly affected by immunosuppressive and antiviral drugs.
You May Also Like
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
FEB 24, 2021
10:00 AM PST
C.E. CREDITS
FEB 24, 2021
10:00 AM PST
DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
MAR 16, 2021
10:00 AM PDT
C.E. CREDITS
MAR 16, 2021
10:00 AM PDT
Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
APR 21, 2021
10:00 AM PDT
C.E. CREDITS
APR 21, 2021
10:00 AM PDT
Date: April 21, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Serological testing for SARS-CoV-2 has been steadily adopted into clinical practice over the course of this pandemic. In this webinar,...
MAR 18, 2021
8:00 AM PDT
C.E. CREDITS
MAR 18, 2021
8:00 AM PDT
DATE: March 18, 2021 TIME: 8:00am PDT Sequencing of bulk cells, single cells, and nuclei is opening doors in the understanding of complex biological processes....
APR 01, 2021
8:00 AM PDT
C.E. CREDITS
APR 01, 2021
8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
AUG 21, 2014 9:45 AM PDT
Share
Shotgun sequencing enables non-invasive monitoring of infection and rejection in transplantation
Presented at:
Genetics and Genomics
Specialty
Clinical Microbiology
Dna Sequencing
Personalized Medicine
Clinical Diagnostics
Immunity
Cancer Diagnostics
Immunotherapy
Bioinformatics
Flow Cytometry
Antibiotics
Immuno-Oncology
Human Genetics
Gene Expression
Dna
Big Data
Geography
North America50%
Europe50%
Registration Source
Website Visitors100%
Job Title
Student50%
Medical Laboratory Technician50%
Organization
Medical Center50%
Academic Institution50%
Loading Comments...
Finish Registering
-
AUG 05, 2021Lab Compliance Connect -
AUG 25, 2021Neuroscience 2021
-
SEP 07, 2021Microbiology Virtual Week 2021
-
SEP 08, 2021xMAP® Connect Virtual Conference (On-Demand)
-
SEP 14, 2021Advancing Science: Virtual Immunology Conference
- See More
-
JUL 30, 2021
-
JUL 30, 2021
-
JUL 30, 2021
- See More
