APR 20, 2021 5:00 PM CEST

Researchers share their Spatial Discoveries in Cancer Research

Speakers
  • Associate Prof. at Leiden University Medical Center
    Biography
      Principal Investigator of the Cancer Immunogenomics research group at the department of Pathology of the Leiden University Medical Center. His group develops work on several aspects on cancer immunology and genomics with a particular focus on colorectal and pancreatic cancers. The group's translational aims are to: 1) identify cancer-specific antigens that can be targeted by immunotherapy and 2) elucidate the potential of immune cell subsets other than T cells for immunotherapeutic exploitation. These aims are accompanied by a strong curiosity in understanding and mapping out the complex and multicellular nature of anti-cancer immune responses.
    • MRC Clinical Research Training Fellow
      Biography
        Vasilis is a medical doctor who completed his junior surgical training in Oxford and London. He holds two postgraduate degrees in molecular medicine and mathematical statistics from Imperial College and the University of London, and is currently completing a PhD on prostate cancer at UCL under Prof. Mark Emberton, Prof. Caroline Moore and Dr. Hayley Whitaker. In 2018, he was awarded a Clinical Research Training Fellowship by the UK Medical Research Council for his research, which aims to explore the association between the prostate tumour microenvironment, inflammation and MRI phenotypes commonly seen in the prostate.

      Abstract
      Date:  April 20, 2021
      Time: 8:00am (PDT),  11:00am (EDT),  5:00pm (CEST)
       
       
      Spatial Answers on Oncology - Professor Joan Seoane
      Prof. Joan Seoane, Group Leader and Director of the Translational Research program at the Vall d'Hebron Institute of Oncology (VHIO), Professor of the Autonomous University of Barcelona and EACR Secretary general will chair the session as EACR representative.
       
      Reconstructing colorectal cancer tumorigenesis with spatial transcriptomics - Noel De Miranda
      We applied the GeoMX Digital Spatial Profiler to investigate transcriptional alterations associated with colorectal cancer onset and progression. The expression of approximately 1800 genes was investigated in epithelial and stromal fractions of regions containing healthy mucosa, different degrees of dysplasia, and cancer. Several genes/pathways were associated with oncogenic transformation and progression in cancer cells but also in stromal/immune cell compartments.
       
       
      The transcriptomic evolution of radiologically progressing prostate cancer - Vasilis Stavrinides
      Imaging-based active surveillance of early prostate cancer is an exciting new alternative to radical treatments. Understanding disease progression on MRI is not only important for personalising surveillance schedules and detecting high-risk disease in a timely manner, but also for appreciating the longitudinal history of focal lesions. Here, pilot spatial transcriptomic data from progressing but untreated prostate cancer will be presented.
       
      Learning Objectives:
      • Discover Spatial Genomics in Cancer Research
      • Learn from your peers about Oncology Spatial Discovery
      • Find out about the new EACR Spatial Genomics grant
       
      • April 20: Reasearchers share their Spatial Discoveries in Cancer Research
        • Topics
          • Reconstructing colorectal cancer tumorigenesis with spatial transcriptomics - Noel De Miranda
          • The transcriptomic evolution of radiologically progressing prostate cancer - Vasilis Stavrinides
       
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