APR 09, 2020 8:00 AM PDT

Strategies to achieve robustness in clinical proteomics research

Sponsored by: Agilent
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor, QIMR Berghofer Medical Research Institute, Brisbane Australia
    Biography
      Associate Professor Michelle Hill obtained her PhD at the University of Queensland, Brisbane, Australia, then under took postdoctoral research in Switzerland, Ireland, and back at University of Queensland. Her research training focussed on various aspects of cell signalling and membrane microdomain function using techniques in biochemistry, cell biology and subcellular proteomics. With a passion for translational medical research, Michelle established the Cancer Proteomics Group at the University of Queensland Diamantina Institute on the Princess Alexandra Hospital campus, Brisbane, Australia in 2009. Through interdisciplinary collaborations, her team implemented a mass spectrometry-based amyloidosis typing diagnostic test, which continues to benefit patients in the Australasia region.
      In April 2017, Michelle's research began a new chapter at the QIMR Berghofer Medical Research Institute, Brisbane, Australia, where she also directs the Metabolomics Core Facility. The Precision and Systems Biomedicine Laboratory has been focusing on obesity-associated cancers, with specific projects on translating blood glycoprotein biomarkers for oesophageal adenocarcinoma, understanding lipid-driven mechanisms in cancers focussing on membrane microdomains and extracellular vesicles. The team also collaborates with other researchers on biomarker discovery and development of targeted mass spectrometry tests.

    Abstract
    DATE:  April 9, 2020
    TIME:   8:00am PT, 11:00am ET
     
    Mass spectrometry-based proteomics allows the simultaneous measurement of a large number of proteins and has been widely used for protein biomarker discovery and validation. Quantitative proteomics techniques were primarily developed with small sample numbers, but research involving clinical cohorts requires robust quantitation over a large number of samples. To ensure data accuracy, additional technical and analytical quality control measures need to be implemented in proteomics research involving clinical research cohorts. This webinar will discuss the key considerations and suggest some strategies that has proved useful in clinical research study design.
     
    Learning Objectives:
    • Types of quantitative proteomics techniques applicable for clinical research
    • Challenges and considerations when applying quantitative proteomics in clinical research cohorts
    • Strategies to improve experimental and data reproducibility in quantitative proteomics research
     
    For Research Use Only.  Not for use in diagnostic procedures.
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.
     
     

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