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DEC 06, 2022 8:00 AM PST

From Structure to Function: Combining the Power of Cryo Electron Microscopy and Mass Spectrometry for Deeper Insights

Speakers

Abstract
Date:  December 06, 2022
Time: 8:00am (PST),  11:00am (EST), 5:00pm (CET)
 
Scientist must look beyond studying individual proteins and examine the structure and assembly of protein complexes within cells in order to truly understand how proteins function in their native environment. The emergence of cryo-electron microscopy (cryo-EM) has resulted in the ability to directly visualize complete macromolecular complexes in near-atomic level resolution. Combined with advances in mass spectrometry (MS), these methods have had a considerable impact on structural biology research, enabling researchers to characterize biomolecular structures with greater speed, sensitivity and selectivity. Dr. Pascal Albanese discuss the characterization of a key enzyme of the central carbon metabolism of Pyrococcus furious, through an integrative approach combining structural mass spectrometry, cryo-electron microscopy, mass photometry and molecular modelling with molecular dynamics simulations. He will describe how his lab unveiled the structural organization of phosphoenolpyruvate synthase (PPSA).
 
Learning Objectives
  • Discover the value of using cryo-em microscopy to understand protein structure and function
  • Discuss insights gained by incorporating crosslinking reagents with MS analysis
  • Explain the importance of standardized sample prep to establish robust end-to-end workflow solutions

 

Webinars will be available for unlimited on-demand viewing after live event.
 
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

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