SEP 12, 2012 09:00 AM PDT

Technology & Open Access Human Genome, Environment & Trait data

  • Professor of Genetics, Director of the Center for Computational Genetics, Harvard Medical School
      Professor of Genetics, Harvard Medical School, Director of the Center for Computational Genetics. 1984 Harvard PhD included the first direct genomic sequencing method, molecular multiplexing tags, which lead to automation & software used at Genome Therapeutics Corp. for the first commercial genome sequence -- pathogen, Helicobacter in 1994. This multiplex solid-phase sequencing evolved into polonies (1999), ABI-SOLiD (2005) & open-source (2007). Innovations in DNA reading, writing & allele replacement in cells lead to current research & commercialization in human genomics (Complete Genomics,, 23andme, Knome) , synthetic biology (SynBERC, Joule, LS9) & new ethics/security strategies.



    The Project ( enables open observation and critique of a large cohort "test-driving" comprehensive participatory personalized medicine. This is the only fully open-access human Genome + Environment = Trait (GET) data, with similar open-access stem cells, and clinical community curation/interpretation tools ( This involves inherited genomes plus day-to-day genomic variation -- cancers, microbes, allergens, vaccines, & subcellular-resolution epigenomics. We are also sequencing centenarians. These go beyond diagnostics to genome engineering technologies for stem cell, synthetic organ, microbiome and immunome transplantation therapies. Since 1977, we have helped push the cost of reading and writing DNA (and biological systems) down -- and since 2004 by a million-fold (5-fold faster exponential than Moore's law). Currently we focus on nanopore and in situ sequencing methods.


    Show Resources
    Loading Comments...