The Project (PersonalGenomes.org) enables open observation and critique of a large cohort "test-driving" comprehensive participatory personalized medicine. This is the only fully open-access human Genome + Environment = Trait (GET) data, with similar open-access stem cells, and clinical community curation/interpretation tools (Evidence.PersonalGenomes.org). This involves inherited genomes plus day-to-day genomic variation -- cancers, microbes, allergens, vaccines, & subcellular-resolution epigenomics. We are also sequencing centenarians. These go beyond diagnostics to genome engineering technologies for stem cell, synthetic organ, microbiome and immunome transplantation therapies. Since 1977, we have helped push the cost of reading and writing DNA (and biological systems) down -- and since 2004 by a million-fold (5-fold faster exponential than Moore's law). Currently we focus on nanopore and in situ sequencing methods.