SEP 12, 2012 9:00 AM PDT

Technology & Open Access Human Genome, Environment & Trait data

Speaker
  • Professor of Genetics, Director of the Center for Computational Genetics, Harvard Medical School
    Biography
      George M. Church, PhD '84, is professor of genetics at Harvard Medical School, a founding member of the Wyss Institute, and director of PersonalGenomes.org, the world's only open-access information on human genomic, environmental, and trait data. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all "next generation sequencing" methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications - including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. Church is director of IARPA & NIH BRAIN Projects and National Institutes of Health Center for Excellence in Genomic Science. He has coauthored 450 papers, 105 patents, and one book, "Regenesis". His honors include Franklin Bower Laureate for Achievement in Science, the Time 100, and election to the National Academies of Sciences and Engineering.

    Abstract

     

    The Project (PersonalGenomes.org) enables open observation and critique of a large cohort "test-driving" comprehensive participatory personalized medicine. This is the only fully open-access human Genome + Environment = Trait (GET) data, with similar open-access stem cells, and clinical community curation/interpretation tools (Evidence.PersonalGenomes.org). This involves inherited genomes plus day-to-day genomic variation -- cancers, microbes, allergens, vaccines, & subcellular-resolution epigenomics. We are also sequencing centenarians. These go beyond diagnostics to genome engineering technologies for stem cell, synthetic organ, microbiome and immunome transplantation therapies. Since 1977, we have helped push the cost of reading and writing DNA (and biological systems) down -- and since 2004 by a million-fold (5-fold faster exponential than Moore's law). Currently we focus on nanopore and in situ sequencing methods.

     


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