NOV 03, 2016 10:30 AM PDT

The High Resolution Solution: Accurate Mass for the Clinical Research Laboratory

C.E. CREDITS: P.A.C.E. CE | Florida CE
  • R&D Specialist, ARUP
      Natalie Rasmussen grew up in the Salt Lake City, UT area and earned a BS in biology from the University of Utah in 2004. She began working in the toxicology area at ARUP Laboratories in 2005, where she prepared samples and analyzed them via immunoassay and mass spectrometry. Natalie accepted a position as research and development specialist in ARUP's Institute for Clinical and Experimental Pathology in 2012, where she primarily works on Time-of-Flight mass spec-based testing. She also has some experience with immunoassay and MADLI-TOF. In her free time, she enjoys exploring the playground that is Utah by hiking and camping. She also enjoys reading, cooking, playing softball, and attending sporting events, especially at the University of Utah.


    Liquid chromatography high resolution time-of-flight mass spectrometry (LC-TOF-MS) is becoming increasingly popular in the clinical research laboratory. It can offer higher throughput and superior specificity to the more traditional tandem mass spectrometry (LC-MS/MS) methods. In addition, LC-TOF-MS has the ability to collect full scan data, which allows for down-stream data mining. This talk will discuss time-of-fight mass spectrometry fundamentals; including theory, method development strategies, pros and cons of LC-TOF-MS as compared to LC-MS/MS, and a few lessons our laboratory has learned along the way. 

    Learning Objectives:

    • Describe how time-of-flight mass spectrometry works
    • Compare and contrast TOF-MS with LC-MS/MS
    • Assess what you will need in order to integrate TOF-MS into your laboratory

    For Research Use Only. Not for use in diagnostic procedures.

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