OCT 17, 2013 1:00 PM PDT

Transcriptome sequencing in translational oncology research

C.E. Credits: CE
Speaker
  • Assistant Professor Department of Surgery, Division of General Surgery, Indiana University School of Medicine Indiana University Melvin and Bren Simon Cancer Center IU Center for Computationa

Abstract

Invading cancer cells leave the tumor to form distant metastases and are ultimately responsible for 90% of deaths in cancer. Reducing the ability of cancer cells to invade and metastasize could extend the life of cancer patients. However, our current understanding of the conditions that trigger and guide the invasion of cancer cells is insufficient and our abilities to interfere with these processes are limited. By using novel microfluidic tools, we uncovered an unexpected ability of cancer cells to navigate and exit microscopic mazes along the shortest path. To explain this behavior, we propose a novel mechanism that guides cancer cell migration. This mechanism depends on the generation of spatial chemical gradients by the cancer cell themselves, through the competition between epidermal growth factor (EGF) uptake by the cells and the restricted diffusion of EGF from surrounding microenvironment to the cells. Employing this strategy when placed in uniform but confined environments, cancer cells can self-generate spatial gradients of EGF, effectively mapping the environment, and guiding their own escape from the confinement. Better understanding of the cancer cell guidance strategy by self-generated gradients could lead to approaches for restricting the migration of malignant cells to delay local invasion and distant metastases. Learning objectives: - Identify the environment settings that trigger self-guided cell migration; - Recognize the conditions that favor cancer cell invasion; - Predict the patterns of cancer cell migration in various conditions of confinement; - Suggest interventions that may perturb the self-guidance of cancer cells.


Show Resources
You May Also Like
APR 07, 2020 8:00 AM PDT
C.E. CREDITS
APR 07, 2020 8:00 AM PDT
DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
FEB 19, 2020 11:00 AM PST
C.E. CREDITS
FEB 19, 2020 11:00 AM PST
DATE: February 19, 2020TIME: 11:00am PST, 2:00pm EST...
JUN 17, 2020 1:30 PM PDT
C.E. CREDITS
JUN 17, 2020 1:30 PM PDT
Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
FEB 26, 2020 9:00 AM PST
C.E. CREDITS
FEB 26, 2020 9:00 AM PST
DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
MAY 08, 2020 10:00 AM PDT
C.E. CREDITS
MAY 08, 2020 10:00 AM PDT
DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
MAR 11, 2020 6:00 AM PDT
C.E. CREDITS
MAR 11, 2020 6:00 AM PDT
The locomotion of humans and other animals requires a seamless flow of information from sensory modalities all the way to the motor periphery. As such, locomotion is an excellent system for...
Loading Comments...
Show Resources