Keynote Presentation: Translationally Relevant Humanized Mouse Studies: Practical Refinements that Reduce Variability and Improve Reproducibility

Humanized immune system (HIS) mouse models are increasingly central to immuno-oncology and immune-modulating drug development, yet study-to-study variability can limit translational confidence. This webinar discusses practical refinements aligned with 3Rs principles that reduce experimental noise, improve animal welfare, and enhance reproducibility. Topics include donor selection strategy, engraftment consistency, study design controls, and integrated immune monitoring approaches. Attendees will gain actionable considerations to strengthen data quality and improve the translational relevance of HIS-based preclinical studies.