NOV 02, 2016 10:30 AM PDT

Urine Drug Testing in Pain Management

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  • Associate Professor of Pathology, Clinical Toxicology, Director, Point-of-Care Testing, Johns Hopkins University School of Medicine
      Dr. William Clarke is an associate professor of pathology at the Johns Hopkins University School of Medicine. His research focuses on the development of analytical methods for drug analysis, clinical mass spectrometry, and devices for point-of-care testing. Dr. Clarke serves as the director of Clinical Toxicology as well as Critical and Point-of-Care Testing Program at The Johns Hopkins Hospital.

      His team's current projects include qualitative screening for antiretroviral drugs and substances of abuse in various HIV- prevention clinical trials, development and validation of mass spectrometry methods for clinical analysis, and development of clinical assays for use on microfluidic platforms.

      Dr. Clarke received his B.S. in Chemistry from the University of Nebraska at Kearney and his Ph.D. in Analytical Chemistry from the University of Nebraska-Lincoln, as well as an M.B.A. from the Carey School of Business at Johns Hopkins University. He completed a post-doctoral fellowship in Clinical Chemistry at the Johns Hopkins School of Medicine.


    With increasing emphasis on effective pain management in clinical care, there has been a significant increase in the number of opioid prescriptions in the past decade.  While these drugs are effect in treating chronic pain, they also have a high potential for addiction and abuse.  Given this paradigm, it is increasingly important to identify patients at risk for abuse, misuse or diversion of these drugs.  There are several clinical risk assessment tools available, but these are dependent on accurate self-reporting by the patient. Urine drug testing provides an objective measurement that can be used to supplement clinical presentation and survey tools for risk assessment, and has become a vital part of pain management practice.  This presentation will discuss challenges in pain management, review available survey tools for risk assessment, and then give an overview of opportunities and challenges in laboratory support for pain management patients.

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