Webinars

JAN 28, 2021 7:00 AM PST

Utilization of Optical Genome Mapping in Detection and Characterization of Rare Genetic Markers in Pediatric Leukemias

Sponsored by: Bionano

Speaker

Gordana Raca, MD, PhD, FACMG

Director, Cytogenomics Laboratory, Department of Pathology and Laboratory Medicine at Children's Hospital Los Angeles, Associate Professor of Clinical Pathology, Keck School of Medicine, USC
BIOGRAPHY

Event Date & Time

Date: January 28, 2021

Time: 7:00am (PST), 10:00am (EST)

Abstract

Many of the newly recognized clinically significant genetic markers in pediatric leukemias cannot be reliably detected by routine diagnostic assays; they remain cryptic by karyotype analysis and are typically not interrogated by FISH testing or by diagnostic next-generation sequencing panels.

In this webinar, Dr. Raca will present results of a pilot study in which Optical Genome Mapping (OGM) revealed clinically significant structural variants in pediatric leukemias, which were missed by comprehensive multi-modal clinical testing. She will also illustrate the application of OGM to study a rare structural abnormality of the PAX5 gene in pediatric B-lymphoblastic leukemia, which could not be accurately characterized by other molecular methods.

Learning Objectives

Outline the main advantages of OGM compared to conventional cytogenetics (karyotype analysis).
Summarize how application of OGM facilitates detection of rare clinically significant structural variants in pediatric leukemias
Describe how application of OGM facilitates detection and characterization of repeat expansions in constitutional disorders and tumor samples.

Webinars will be available for unlimited on-demand viewing after live event.

LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

Show Resources

Utilization of Optical Genome Mapping in Detection and Characterization of Rare Genetic Markers in Pediatric Leukemias

Gordana Raca, MD, PhD, FACMG