Versatility of mass photometry for the structural characterization of biomolecular assemblies present in blood

In this webinar recent applications of mass photometry are highlighted especially focusing on higher-order protein assemblies as present in our blood. In particular, the ability of mass photometry to mass analyze co-occurring assemblies is showcased. Based on the mass photometry data, improved structural models could be proposed for the C4b-binding protein (C4BP) macromolecular assembly, and better insight was attained about how multivalency in antibody therapeutics can be exploited to optimize antibacterial biotherapeutics. More, generally the webinar showcases how mass photometry complements other techniques in structural biology, such as (glyco)proteomics, cross-linking mass spectrometry, native mass spectrometry, computational modelling and single molecule mass spectrometry.

Event Takeaways

• Mass photometry is an easy to use versatile method
• Mass photometry can expose the purity of protein assemblies
• Mass Photometry can be used to quantify the presences of co-occurring protein assemblies
• There are spiders in your blood
• In some cases IgM may outperform IgG as biotherapeutic