SEP 02, 2020 12:00 PM SGT

Combining immunodiagnostics and immunotherapy for clinical management of infectious complications in transplant patients

Speaker

Abstract

Viral infections are an extremely common and predictable problem in organ and hematopoietic stem cell transplant patients. Antiviral drugs given either prophylactically or as early therapy for patients detected to be shedding virus appears to be an effective strategy for reducing herpes virus infections. However, long-term treatment with these drugs is associated with significant toxicity, expense and the appearance of drug resistance virus isolates ultimately resulting in treatment failure. Over the last few years, there is increasing evidence that cellular immune therapies can reverse the outgrowth of hematological malignancies and can also provide therapeutic benefit against lethal viral infections. While the expansion and adoptive transfer of virus-specific T-cells from the healthy original donor can be an effective strategy to control viral replication, this is not possible when donors are seronegative or are subsequently inaccessible. Studies from our group have demonstrated the successful expansion of human cytomegalovirus (CMV) and Epstein-Barr virus (EBV)-specific T-cells from solid organ and stem cell transplant recipients with active viral infection or disease and the long term reconstitution of protective anti-viral immunity following their adoptive transfer back into the patients. More recently, we have also developed a single platform technology to extend this immunotherapeutic strategy for multiple pathogens including CMV, EBV, adenovirus and BK polyoma virus. T cells directed towards multiple pathogens can be rapidly expanded and can be used for adoptive immunotherapy. Finally, in collaboration with an Australian biotech company, Cellestis Inc., we have also developed a novel T cell-based immune monitoring technology (QuantiFERON-CMVâ) which will allow us to identify high risk transplant patients who may develop virus-associated complications post-transplantation.


Show Resources
You May Also Like
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
DEC 01, 2021 7:00 AM PST
C.E. CREDITS
DEC 01, 2021 7:00 AM PST
Date: December 01, 2021 Time: 7:00am (PST), 10:00am (EST) In the era of immuno-oncology, there is a growing need for the identification of new biomarkers predictive for sensitivity to anti-P...
SEP 16, 2021 8:00 AM PDT
C.E. CREDITS
SEP 16, 2021 8:00 AM PDT
Date: September 16, 2021 Time: 8:00am (PDT), 11:00am (EDT) Rapid screening and speed of scale-up in protein therapeutics are critical factors in today’s biotech and pharma workflows. T...
DEC 07, 2021 10:00 AM PST
C.E. CREDITS
DEC 07, 2021 10:00 AM PST
Date: December 07, 2021 Time: 10:00am (PST) The RNAscope™ technology allows high sensitivity and spatial resolution providing pivotal single-cell information to gain better insights in...
JUN 24, 2021 8:00 AM PDT
C.E. CREDITS
JUN 24, 2021 8:00 AM PDT
Date: June 24, 2021 Time: 8:00am (PDT), 11:00am (EDT) Cardiovascular disease is a leading health problem, affecting almost 30% of individuals in the developed world, and comprises a wide ran...
Loading Comments...
Show Resources