MAY 30, 2013 8:00 AM PDT

VITROS® Microslide Technologies / Assays

Speaker
  • Director, Scientific Affairs, Ortho Clinical Diagnostics
    Biography
      John Backus, Ph.D. is Director, Scientific Affairs, Ortho Clinical Diagnostics, Part of the Johnson & Johnson Family of Companies. John has 20 years of experience in the In Vitro Diagnostics (IVD) industry. He has held a variety of scientific / managerial positions at Eastman Kodak, Gen-Probe, Sigma, Veridex, and Ortho Clinical Diagnostics, primarily focused on IVD Assay / Technology Development and Clinical Verification and Validation of diagnostic biomarkers to address significant unmet needs in Metabolic Disease, Cardiovascular Disease, Acute Care, Oncology, Reproductive Health, and Infectious Disease. John led the development of the first FDA-approved intra-operative molecular cancer diagnostic and has 13 issued U.S. patents, primarily related to nucleic acid purification, amplification, and detection technologies. John received his Ph.D. in Biochemistry from the University of Rochester. His thesis research focused on elucidation of the RNA sequence elements required for mammalian apoB mRNA editing by the editosome macromolecular complex.

    Abstract

    VITROS® Microslides utilize a layered, dry-slide technology that enables separate reaction domains such that each step can be optimized to provide excellent assay performance. Excellent precision and accuracy are achieved through designs that combine multiple discrete layers of spreading, masking, scavenger, and other reagent layers. Dry-slide methods use traditional, well-accepted analytical principals and are traceable to accepted reference methods, so that results are consistent over time and around the world. This presentation will focus on three differentiating features of VITROS® Microslide technology: 1) minimization of paraprotein interference in chemistry assays, 2) direct potentiometric measurement of sodium utilizing a disposable ion selective electrode (ISE), and 3) direct measurement of unconjugated, conjugated, and total bilirubin utilizing reflectance spectrophotometry. All three of these features have been demonstrated to improve the clinical/analytical accuracy of assay results.  


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