JUN 22, 2016 08:00 AM PDT

Applications of targeted NGS panels for clinical research of primary immunodeficiency diseases

Speakers
  • Assistant Professor at Boston Children's Hospital and Harvard Medical School
    Biography
      Janet Chou is an Assistant Professor of Pediatrics at Harvard Medical School and an allergy/immunologist at Boston Children's Hospital. Her research focuses on the genetic and molecular mechanisms underlying human primary immunodeficiencies, with an emphasis on identifying rational targeted approaches for immunomodulation. Her experience as a clinical immunologist drives her search for more precise and rapid ways of understanding immune dysregulation. Janet received her M.D. from Harvard Medical School. She completed a residency in pediatrics and a fellowship in allergy and immunology, both at Boston Children's Hospital.
    • Research Technologist, Boston Children's Hospital
      Biography
        Wayne Bainter is a Research Technologist at Boston Children's Hospital. His expertise encompasses the application of genetic approaches in the study of human immune disorders, functional analysis of the immune system, and characterization of murine models of human disease. In his current role, he is leading the targeted next-generation sequencing initiative in the Geha Laboratory at Boston Children's Hospital. Wayne graduated from Salve Regina University with a BS in Biology and minor in Chemistry.

      Abstract:
      Primary immunodeficiencies (PIDs) are a group of more than 250 genetic disorders that disrupt the immune system, resulting in susceptibility to life-threatening infections, autoimmune disease, or malignancy. 

      Identifying the genetic causes of PIDs is essential for understanding the molecular pathways leading to these diseases, but is challenging because of phenotypic heterogeneity, pleiotropy, and the accessibility of genetic testing.

      The advent of next-generation sequencing (NGS) has been instrumental in accelerating the pace of discovery in the field of PID research and testing. NGS enables high-throughput screening of many genes in a rapid, cost-effective manner and thus has the potential to transform the strategies and workflow of research on PIDs. 

      In this webinar, our expert speakers will discuss how they implemented a next-generation sequencing approach to PID research in a translational research lab. They will present their hands-on experience in utilizing a targeted NGS panel, compare it to conventional approaches for studying PIDs, and demonstrate the applications of this technology to translational research in PIDs.

      For Research Use Only. Not for use in diagnostic procedures.

      Show Resources
      You May Also Like
      AUG 16, 2018 08:00 AM PDT
      C.E. CREDITS
      AUG 16, 2018 08:00 AM PDT
      DATE: August, 16, 2018TIME: 08:00AM PDTThis webinar will review recent advancements in the application of next-generation sequencing of T cell receptor beta (TCRB) chain repertoires towards...
      JUN 26, 2018 06:00 AM PDT
      C.E. CREDITS
      JUN 26, 2018 06:00 AM PDT
      Date: June 26, 2018Time: 6:00 a.m. PDT, 9:00 a.m. EDT, 1500 CEST Today’s hematology analyzers employ various methods for enumerating platelets. These methods include: e...
      APR 25, 2018 07:00 AM PDT
      C.E. CREDITS
      APR 25, 2018 07:00 AM PDT
      DATE: April 25, 2018TIME: 1500 CET, 10:00 a.m. EST, 7:00 a.m. PST Hematology and coagulation laboratories perform a wide range of routine and specialized tests, allowing clinicians to...
      MAY 22, 2018 08:00 AM PDT
      C.E. CREDITS
      MAY 22, 2018 08:00 AM PDT
      DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
      MAY 24, 2018 09:30 AM PDT
      C.E. CREDITS
      MAY 24, 2018 09:30 AM PDT
      DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
      JUN 20, 2018 10:00 AM EDT
      C.E. CREDITS
      JUN 20, 2018 10:00 AM EDT
      DATE: June 20, 2018TIME: 07:00AM PDT, 10:00AM EDTIntroducing GE’s New Lyo-StableTM service. Sepsis is one of the top challenges facing hospitals in terms of clinical outcomes...
      Loading Comments...