Chief Technology Officer, Managing Director & Co-Founder, ions.bio
BIOGRAPHY
Speaker
Event Date & Time
Date: October 21, 2025
Time: 9:00 AM (PT), 12:00 PM (ET), 6:00 PM (CET)
Abstract
Plasma proteomics offers great promise for biomarker discovery, due to the accessibility and diagnostic relevance of blood plasma. Recent advances in instrumentation, particularly the Orbitrap Astral mass spectrometer, now enable unprecedented depth, with over 1,000 proteins routinely quantified directly in neat plasma, without the need for depletion or fractionation. This development is transforming the landscape of high-throughput biomarker research.
In addition, nanoparticle- or precipitation-based enrichment workflows can further expand proteome coverage, offering orthogonal strategies to access low-abundance proteins and diverse functional subsets. However, all these approaches remain highly susceptible to pre-analytical variation. Factors such as sample collection, handling, and storage can introduce significant bias, confounding both discovery and interpretation. Therefore, rigorous standardization and quality control are critical to ensure reproducibility and biological relevance.
We will illustrate both the challenges and opportunities of plasma biomarker discovery using two example cohorts: one from bariatric surgery and one from patients with Giant Cell Arteritis. Together, these case studies highlight how deep plasma proteomics can uncover disease-relevant signals, while also underscoring the need for methodological care to ensure robust biological insights.
Learning Objectives:
- Understand the analytical challenges of plasma biomarker discovery for cohort studies
- Learn about technology advancements to improve depth and throughput for plasma biomarker discovery
- How to apply best practices for standardization and quality control in plasma proteomics
- What workflow developments can be leveraged to uncover disease relevant signals in sample cohorts
Webinars will be available for unlimited on-demand viewing after live event.
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