JUL 14, 2016 6:00 AM PDT

Innovations in Hepatology: Biomarkers for Hepatocellular Carcinoma in Surveillance and Management of patients with Chronic Liver Disease

Speaker
  • Chair of Gastroenterology Fellowship Research Committee, Associate Professor of Clinical Science, UT Southwestern Medical Center
    Biography
      Dr. Amit G Singal is an Associate Professor of Medicine and Medical Director of the Liver Tumor Program at UT Southwestern Medical Center. He received his Graduate Degree in Biology and Doctor of Medicine from the University of Michigan, Ann Arbor. He also earned two Master of Science degrees, the first from the University of Michigan in Health and Health Care Research and the second in Clinical Sciences from the University of Texas Southwestern in Dallas. Dr. Singal is Board Certified in Gastroenterology and Transplant Hepatology by the American Board of Internal Medicine. He is a member of several professional society committees and serves as Chair of the International Liver Cancer Association (ILCA) Surveillance and Biomarkers Special Interest Group. He is on the editorial board of several journals including Seminars in Liver Disease, Clinical Gastroenterology and Hepatology, Clinical Translational Gastroenterology, and PLOS Medicine. Dr Singal has published over 50 peer-reviewed scientific papers and over 20 review articles/textbook chapters on Hepatocellular Carcinoma.

    Abstract

    Hepatocellular Carcinoma (HCC), the third leading cause of global cancer mortality, continues to be a substantial burden to health systems, society and individuals at risk. Although prognosis is poor among most patients with HCC, with 5-year survival rates below 10%, frequent monitoring of at-risk patients is associated with improved early detection and survival rates. Patients with cirrhosis from any cause, including chronic hepatitis C, hepatitis B, and nonalcoholic steatohepatitis, may benefit from screening regimens, such as ultrasonography and serum biomarker monitoring. To date, abdominal ultrasound with or without alpha fetoprotein (AFP) is the preferred method for HCC screening in high-risk patients.

    Despite the relative low cost and non-invasive nature of these techniques, there is a potential opportunity to improve sensitivity and specificity of HCC detection by leveraging newly available serum biomarkers. PIVKA-II, also known as DCP, is a modified prothrombin that lacks the activity of interacting with other coagulation factors and is expressed in HCC cells. PIVKA-II has been used alongside ultrasound and AFP for HCC screening programs and HCC diagnosis in certain geographies (i.e. Japan).

    During this webinar we will review the epidemiological and clinical landscape of hepatocellular carcinoma. We will discuss current challenges and opportunities in HCC surveillance and patient management, including the role of biomarkers, including AFP and PIVKA-II.


    Show Resources
    You May Also Like
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    SEP 03, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 03, 2020 9:00 AM PDT
    DATE: September 3, 2020 TIME: 09:00am PT, 12:00pm ET xxx Learning Objectives: xxx Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provi...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    C.E. CREDITS
    This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
    Loading Comments...
    Show Resources
    Attendees
    • See more