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Inflammation is associated with cognitive decline and the pathogenesis of Alzheimer's disease, although exact pathways remain elusive. To further explore the role of inflammation, we uti...
How do we gain a comprehensive understanding of the mechanisms underlying complex behaviors occurring in complex and dynamic environments? Almost any answer to this question involves a multi...
Brian Uzzi presents two studies on innovation in science. Study one examines conditions favoring the generation of innovative, high impact ideas and study two examines the conditions that ef...
The rapid growth of technologies capable of comprehensively collecting, managing, and allowing us to gain an in-depth picture of the brain, nervous system, and behavior across diverse spatia...
Learning Objectives: 1. Describe language disturbances in schizophrenia and its risk states. 2. Describe face expression disturbances in schizophrenia and its risk states. 3. Describe ethica...
The nervous system of social species has evolved to perceive and evaluate signals within a social context. Social information therefore must impact how the brain processes information, yet l...
Join us for a thought-provoking webinar titled, "Breaking Barriers in STI Clinical Management: Addressing Resistance Challenges and Incorporating New Diagnostic Approaches," featur...
Parkinson’s disease (PD) belongs the group of synucleinopathies characterized by progressive aggregation of the neuronal protein alpha-synuclein (asyn). Diagnosis and evidence of disea...
Learning Objectives: 1. Review the basic principle of 3D microscopy. 2. Recognize the pathophysiology of Parkinson disease. 3. Demonstrate knowledge on how alpha-synuclein aggregates spread...
The advancement in ultra-sensitive immunoassays and highly specific immunoprecipitation mass spectrometry (IPMS) methods, complimented by an increasing number of well-characterised research...
DBS for obsessive-compulsive disorder (OCD) achieves clinical benefit in 66% of treatment-resistant patients. However, there is still a lack of a fundamental understanding of the neurophysio...
Robots are useful tools for studying the nervous system and its control of body mechanics because they can be used to perform experiments that would be difficult to perform with an animal. F...
Protein misfolding and aggregation are key features observed in numerous neurodegenerative conditions, such as Alzheimer's and Parkinson's disease. The oligomers formed during the ag...
Vestibular sensation anchors our perception of the environment and is crucial for maintaining balance during locomotion. Vertebrate animals use the evolutionarily conserved vestibular system...
The ultimate goal of neuroscience is to understand and explain real-world behavior in terms of brain activity, and to use these insights to develop therapeutic approaches for neural disorder...
Recent advances in gene editing has allowed the generation of advanced rodent research models, mimicking some aspects of human conditions. For neurodegenerative disorders such as Alzheimer&r...
Brain organoids are self-assembled three-dimensional cellular aggregates with cell types and tissue architectures that resemble the embryonic human brain. As they recapitulate many key featu...
Mental health is a multidimensional challenge, marked by rapid brain changes and essential interpersonal relationships. This complicates the application of traditional statistical methods an...
Speech neuroprostheses have the potential to restore communication to people living with paralysis, but naturalistic speed and expressivity are elusive. Here we use high-density surface reco...
Many behaviors are learned through trial and error by matching performance to internal goals, yet neural mechanisms of performance evaluation remain poorly understood. We recorded basal gang...
Drug discovery programs require a robust panel of models and assays to identify and validate drug targets, support compound optimisation, and run mechanistic studies. Fully human in vitro mo...
Infant motor development is measured clinically using short, subjective, observational scales. While these scales are useful, they have limitations. They provide us with a “snapshot&rd...
Social interactions are essential for the survival of social animals. Across species the medial prefrontal cortex (mPFC) has been identified as a hub of social cognition. In mouse models we...
How do the cognitive and physiological traits of individuals translate into real-world group dynamics? There is an empirical and theoretical gap between understanding individual-level proces...
Our ability to record large-scale neural and behavioral data has substantially improved in the last decade. However, the inference of quantitative dynamical models for cognition and motor co...
Social animals congregate in groups and communicate with vocalizations. To study the dynamics of natural vocal communication and their neural basis, one must characterize signals used for co...
Inflammation is associated with cognitive decline and the pathogenesis of Alzheimer's disease, although exact pathways remain elusive. To further explore the role of inflammation, we uti...
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