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One of the main issues in a proteomics experiment is sample preparation. Protocols have been designed to optimize protein extraction, digestion, enrichment, cleaning and labeling (if require...
The treatment of cancer has remarkably improved because of increased knowledge of the molecular abnormalities that drive human cancer growth. This has led to the development of ever more eff...
Recent advances in super-resolution fluorescence microscopy based on single-molecule imaging have led to ~10 nm spatial resolution and exciting science. We are developing new approaches to a...
Homologous recombination repair deficiency (HRD) is associated with response to poly-ADP-ribose polymerase inhibition (PARPi) therapy in advanced ovarian cancer. In combination with CGP, the...
While a decade ago the prognosis of lung cancer patients was very disappointing, nowadays a substantial evolution is driven by targeted treatments and immuno-oncology. With extended, scaled...
High-throughput screening (HTS) is crucial to generate hits and leads in drug discovery efforts. Most high-throughput biochemical assays are based on optical detection or radioactivity with...
In this presentation Shameema Sikder will discuss her career trajectory starting as an undergraduate studying chemical engineering and biochemistry to an Associate Professor of Ophthalmology...
In the field of tumor immunotherapy, cancer vaccines are designed to help the immune system recognize and attack cancer cells. More efforts are needed to identify neoantigens, develop combin...
Interpreting genomic test results for cancer care remains a significant challenge, with variability in turnaround times, reporting standards, and clinical utility impacting patient outcomes....
In the adult mammalian hippocampus, neurogenesis (in which new neurons are generated and integrated into the CNS) is believed to underlie learning and memory. Within the hippocampus, numerou...
This presentation looks at the dynamic landscape of therapeutic antibody development, focusing on next-generation immuno-oncology therapeutics that target checkpoint inhibitors and incorpora...
When I started my faculty job, I thought that just knowing the type of mentor I wanted to be and the lab culture that I wanted to create would be enough to make these things happen. I couldn...
Isobaric labeling enables the multiplexed analysis of up to 18 proteomes or PTMomes in a single analysis and provides information on protein and peptide abundance across all samples simultan...
The cellular thermal shift assay (CETSA) is a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. The principle behind CETSA is that a ligand &nd...
Use your sales data to understand how to maximize efficiency and revenue in your dispensary while also identifying consumer trends early on to put you way ahead of the retail curve....
In the battle between magnetism and superconductivity, magnetism wins so often that only a handful of magnetic superconductors are known. In this context, here we report our characterization...
Cell-based therapeutics show immense promise in treating a variety of currently incurable diseases due to their potent mechanisms. However, despite recent successes, challenges persist in ma...
Despite the increasing number of effective anti-cancer therapies, successful treatment is limited by the development of drug resistance. While the contribution of genetic factors to drug res...
Functional interactions between cytotoxic immune cells and tumor cells are central to anti-cancer immunity. Some of the proteins involved, particularly immune checkpoints expressed by T cell...
Antipsychotic (AP) medications are increasingly recognised for their association with a heightened risk of infections. Clozapine, an atypical AP reserved for treatment-resistant schizophreni...
In the fast-paced world of healthcare-associated infections (HAIs) management, time is of the essence. Traditional diagnostic techniques, which can take days to yield results, often lead to...
Infertility affects one in six couples, with fertility treatments facing daunting 2:1 odds of failure versus success. Emerging research highlights the critical role of vaginal microbiome hea...
Discussion of chikungunya arthritis studies and dengue vascular permeability studies including translation science....
