Stay informed on developments in cancer and oncology diagnosis, prevention and treatment through these curated webinars. As the race toward a cure for cancer continues, advances in cancer research are constantly revealed as innovation in the field of oncology progresses.
One of the central tenets of biology is that our genetics—our genotype—influences the physical characteristics we manifest—our phenotype. But with more than 25,000 human ge...
Breast cancer is the number one cause of cancer in women. Although many risk factors for breast cancer have been identified, only some are modifiable. Since 2004, incidence rates have been r...
Immuno-oncology (IO) is a type of cancer treatment that uses the body's immune system to fight cancer. It works by stimulating the immune system to recognize and attack cancer cells, while le...
Next-generation sequencing (NGS) allows the simultaneous analysis of multiple genomic alterations with therapeutic implications, paving the way for precision medicine and transforming cancer...
Every patient is different and so is every tumor! The term “personalized oncology” today is largely associated with sequencing approaches. Current publications proof more and mor...
Gene regulatory networks are representations of the relationship between transcription factors and their target genes. By modeling gene regulatory networks, it is possible to identify change...
Brain cancer research stands to benefit from the perspectives, tools, and methodologies of non-traditional fields, such as mechanical engineering. Here, I will discuss our engineering-based...
Effective cellular therapies for solid tumors remain elusive. Advances in gene editing and synthetic biology offer great potential for improving the safety and functionality of engineered ce...
We started our experience with prostate cancer in 2002 with primitive robotic platforms. Our main goal was to provide an alternative to open and laparoscopic surgery....
Immunotherapy has changed the landscape of oncology, improving survival rates for many patients across a variety of malignancies. Two antibody-based immunotherapies, immune checkpoint inhibi...
Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieve a durable complete response. Furthermore,...
Mathematical methods can be used to study evolutionary processes associated with carcinogenesis. Selection, mutation, and drift all play a role in cancer dynamics and cancer treatment. I wil...
Precision medicine is transforming cancer care, with next-generation sequencing (NGS) enabling the simultaneous analysis of multiple genomic alterations with therapeutic implications. Howeve...
Antibody-based cancer therapies have clear advantages over chemotherapeutic drugs thanks to their high specificity and low risk of side effects. However, it can be difficult to identify targ...
Cancer neoantigens arise from protein-altering somatic mutations in tumor and rank among the most promising next-generation immuno-oncology agents when used in combination with immune checkp...
In real-world evidence (RWE), temporal shifts in clinical knowledge and practice need to be adjusted for treatment effect assessment. We use electronic health records (EHR) data to 1) assess...
Genomic analysis of cancer cells revealed comprehensive mechanism of tumorigenesis in human patients. Among the abnormalities discovered so far, CNVs accounted for a great portion of all the...
Prostate cancer (PCa) affects one in nine men and is the most diagnosed solid tumor cancer among men in the United States. The introduction of the prostate-specific antigen (PSA) biomarker b...
The majority of disease-associated genetic variants are thought to have regulatory effects, including disruption of transcription factor (TF) binding and alteration of downstream gene expres...
COSMIC is the world’s largest and most comprehensive somatic mutations resource. COSMIC’s contents are manually curated by PhD-level experts from high-quality scientific literatu...
Solute carriers include numerous uptake transporters that serve as major regulators of drug absorption, disposition, and clearance. Indeed, drug interactions or genetic variation that alter...
Competing to offer a comprehensive genomic profiling service for solid or hematology oncology tumor samples is challenging, especially as panels increase in size and complexity. QIAGEN Clini...
The tumor-associated microbiota is an inherent component of the tumor microenvironment across various human cancer types1. Although members of tumor-associated microbiomes can be identified...
Circulating proteins found in biofluids represent ideal biomarkers for early disease detection and can be collected non-invasively. Detection from biofluids, however, is challenging as highl...
The elegant and well-orchestrated molecular players responsible for normal neurodevelopment harbor the capacity for detrimental repercussions if mis-expressed at the wrong time, or in the wr...
Nanovials are emerging as an accessible platform for performing single-cell functional screening leveraging standard instrumentation, such as flow cytometers and microfluidic single-cell seq...
Adoptive cell therapy (ACT) is an immunotherapy that employs living immune cells to target and destroy cancer cells. However, the inhibitory tumor microenvironment features several obstacles...
One of the central tenets of biology is that our genetics—our genotype—influences the physical characteristics we manifest—our phenotype. But with more than 25,000 human ge...
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