Name: "Anti-VAR2CSA (3D7) h(CD28-CD3_) CAR, pMMLV"
Availability: InStock

"Anti-VAR2CSA (3D7) h(CD28-CD3_) CAR, pMMLV" | Creative Biolabs

Recombinant Moloney murine leukemia virus (MMLV) retroviral vectors serve as efficient viral vector tools for introducing genes permanently into a wide variety of dividing cells, and provide an alternative to modify primary T cells. Creative biolabs has developed retroviral CAR vector pMMLV VAR2CSA (3D7) h(28_), which is constructed for the engineering of T cells to target human VAR2CSA. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-VAR2CSA antibody linked to a CD28 transmembrane domain and CD3-zeta signaling domains. And the vector product was designed for the treatment of solid tumors such as melanomas , neuroblastoma.