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Creative Biolabs is the leading custom service provider with extensive experience in various antibody production and engineering fields.
Creative Biolabs
Anti-CD229 (2D3) h(scFv-CD3_) TRuC-Jurkat Cells | Creative Biolabs
The T cell receptor fusion construct (TRuC) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunit can effectively reprogram an intact TCR complex to recognize tumor surface antigens. Unlike CAR, TRuC become a functional component of the TCR complex. TRuC-T cells kill tumor cells as potently as second-generation CAR-T cells, but at significant lower cytokine release and despite the absence of an extra co-stimulatory domain.
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