Name: Anti-CS1 (XP5-47) h(CD28-CD3_) CAR-CIK Cells
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Anti-CS1 (XP5-47) h(CD28-CD3_) CAR-CIK Cells | Creative Biolabs

Cytokine-induced killer (CIK) cells are a heterogeneous population of polyclonal T cells that acquire phenotypic and cytotoxic properties of natural killer (NK) cells through the cultivation process, becoming so-called T-NK cells. CIK cells are capable of killing tumors in an unrestricted major histocompatibility complex (MHC) manner and can be genetically modified to express CARs. Taken together, the promising safety profile of patients in an allogeneic setting, MHC-independent cytotoxicity capability, and unique NK cell-like phenotype make CAR CIK cells a viable alternative for targeting cancer.

Our CAR CIK cells are engineeried by incorporation of second-generation CAR into PBMC-derived CIK cells using the non-viral Sleeping Beauty (SB) transposon or CAR lentivirus transduction technology. These CAR CIK cells are expected to exhibit robust antitumor activity in xenograft mouse models compared to unmodified CIK cells.