Name: Anti-KLK2 (XP5-1721) h(CD28-CD3_) CAR-Treg Cells
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Anti-KLK2 (XP5-1721) h(CD28-CD3_) CAR-Treg Cells | Creative Biolabs

Given the promising results using CARs in targeting hematological malignancies, efforts have been made to use CARs to redirect T cells for other purposes. Adoptive transfer of regulatory T cells (Tregs) for the treatment of various diseases is an active area of research. In contrast to cytotoxic T cells, Tregs can suppress lymphocytes against other antigens in the local microenvironment (often referred to as ""bystander suppression"") without destroying normal cells expressing the target antigen. Several groups have explored the use of CARs to target Tregs to specific immune cell populations in preclinical models of graft-versus-host disease, organ transplantation, and various autoimmune diseases.

Our CAR-Treg cells were designed by incorporating a second-generation CAR into PBMC-derived Treg cells using lentiviral transduction technology. These CAR-Treg cells are expected to lyse tumor cells in vitro and exhibit antitumor functions in vivo.