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Creative Biolabs is the leading custom service provider with extensive experience in various antibody production and engineering fields.
Creative Biolabs
Anti-GM2 (X9X153) h(ICOS-41BB-CD3_) CAR-Jurkat-NFAT-Luc | Creative Biolabs
The Anti-GM2 (X9X153) h(ICOS-41BB-CD3_) CAR-Jurkat-NFAT-Luc cell line is a stable cell line derived from anti-GM2 CAR lentivirus transduction using Jurkat-NFAT-luciferase cell as effector cell. This transduced CAR lentiviral vector was constructed to express scFv of an anti-GM2 antibody linked to the ICOS-41BB-CD3_ signaling domains. The CAR-Jurkat cell line constitutively expressing the firefly luciferase gene under the control of NFAT response elements to facilitate subsequent research. And the recombinant cell product targeted GM2 for CAR-T studies in human Lung Cancer, Neuroblastoma, Glioma, Melanoma, Malignant Mesothelioma.
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