mouse monoclonal IgG2a; XPG Antibody (8H7) is an IgG2a κ mouse monoclonal XPG antibody (also designated XPG antibody) that detects the XPG protein of human origin by WB, IP, IF and IHC(P). XPG Antibody (8H7) is available as both the non-conjugated anti-XPG antibody form, as well as multiple conjugated forms of anti-XPG antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Seven complementation groups (A-G) of xeroderma pigmentosum have been described. The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens. XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair. XPG (also designated ERCC5) is an endonuclease that makes the 3′ incision in DNA nucleotide excision repair. Mammalian XPG is similar in sequence to yeast RAD2. Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair.