mouse monoclonal IgG2a; p15 INK4B Antibody (D-12) is an IgG2a κ mouse monoclonal p15 INK4B antibody (also designated CDKN2B antibody, MTS2 antibody, p15ink4b antibody or p15 antibody) that detects the p15 INK4B protein of human origin by WB, IP, IF and ELISA. p15 INK4B Antibody (D-12) is available as both the non-conjugated anti-p15 INK4B antibody form, as well as multiple conjugated forms of anti-p15 INK4B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6, which are subject to inhibition by the mitotic inhibitory protein, p16 INK4A. An isolated member of the p16 INK4A family has been designated p15 INK4B (also designated, p15, INK4B, CDK4I, TP15, or MTS2). p15 INK4B expression is upregulated approximately 30-fold in TGFβ-treated human keratinocytes, suggesting that p15 INK4B may act as an effector of TGFβ-mediated cell cycle arrest. The gene encoding p15 INK4B (CDKN2B) has been mapped to chromosome 9p21.3 at a position adjacent to the p16 INK4A gene at a site of frequent chromosomal abnormality in human tumors. It has been suggested that p15 INK4B may function as an effector of TGFβ-mediated cell cycle arrest through inhibition of Cdk4 and Cdk6 kinases.