mouse monoclonal IgG1; SMRT Antibody (1212) is an IgG1 κ mouse monoclonal SMRT antibody (also designated Nuclear Receptor Corepressor 2 antibody, SMRT antibody, Thyroid- Retinoic-Acid-Receptor-Associated Corepressor antibody, T3 Receptor-Associating Factor antibody, CTG Repeat Protein 26 antibody, N-CoR2 antibody, TNRC14 antibody, TRAC antibody, Silencing Mediator Of Retinoic Acid And Thyroid Hormone Receptor antibody, SMRTE-Tau antibody, or TRAC1 antibody) that detects the SMRT protein of human origin by WB, IP and IF. SMRT Antibody (1212) is available as both the non-conjugated anti-SMRT antibody form, as well as multiple conjugated forms of anti-SMRT antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Retinoids are metabolites of vitamin A (retinol) and represent important signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) have a high affinity for all trans retinoic acids and belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. Two cofactors that function to repress transcription, designated SMRT (silencing mediator for RARs and thyroid receptors (TR)) and N-CoR, associate with TR and RAR in their unliganded state and are released from them upon ligand binding. The carboxy termini of both proteins contain receptor interacting domains while their amino termini contain two repressor domains. SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.