mouse monoclonal IgG2a; caspase-14 Antibody (D-10) is an IgG2a κ mouse monoclonal caspase-14 antibody (also designated Caspase 14 antibody or CASP14 antibody) that detects the caspase-14 protein of human origin by WB, IP, IF and IHC(P). caspase-14 Antibody (D-10) is available as both the non-conjugated anti-caspase-14 antibody form, as well as multiple conjugated forms of anti-caspase-14 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, and caspase-14. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-14, also designated MICE (for mini-ICE), is highly expressed in embryonic tissues but appears to be absent from adult tissues. Procaspase-14 can be processed in vitro by caspase-8 and caspase-10 but not by other caspases.