Santa Cruz Biotechnology

FOXJ1 (3-19) | Santa Cruz Biotechnology

mouse monoclonal IgG1; FOXJ1 Antibody (3-19) is an IgG1 κ mouse monoclonal FOXJ1 antibody (also designated FOXJ1 antibody) that detects the FOXJ1 protein of mouse, rat and human origin by WB, IP, IF and IHC(P). FOXJ1 Antibody (3-19) is available as both the non-conjugated anti-FOXJ1 antibody form, as well as multiple conjugated forms of anti-FOXJ1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and thus spontaneous autoimmunity, through the repression of NFκB activity. FOXJ1 also inhibits the humoral immune response in B cells; FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation, implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.

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ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.