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    Toxicity studies

    Toxicity studies identify the toxic effects of a drug by studying how it impacts cells or organs within the body. Toxicity studies evaluate both cellular damage but also potential impairment of organ function. These studies often evaluate increasing doses of the drug of interest to determine the highest dose which may be administered safely.

    Webinars

    • DEC 05, 2023 | 8:00 AM
      CGX10 Cell Isolation System:
      CGX10 Cell Isolation System:
      CGX10 Cell Isolation System: Introduction, Utility, and Assessment in a GMP-grade Environment for Multiparametric Cell Sorting A future of long-term, minimally toxic immunotherapy personaliz...
      Speaker: Jerry Barnhart , Manoja Eswara
      Sponsored By: Sony Biotechnology
      13
      NOV 07, 2023 | 10:00 AM
      Understanding the Mechanisms of Resistance in CAR T Immunotherapy for Lymphoma and Strategies to Overcome Them
      Understanding the Mechanisms of Resistance in CAR T Immunotherapy...
      In the last 5 years, the US Food and Drug Administration has approved 4 anti-CD19 chimeric antigen receptor T cell (CART19) products for relapsed/refractory B cell lymphomas and leukemia. Ho...
      Speaker: Marco Ruella
      Sponsored By: Beckman Coulter Life Sciences
      22
      SEP 28, 2023 | 7:00 AM
      Optimizing CAR structures to enhance efficacy in solid tumours; moving from linear to lateral architectures.
      Optimizing CAR structures to enhance efficacy in solid tumours;...
      Webinars will be available for unlimited on-demand viewing after live event. Labroots is approved as a provider of continuing education programs in the clinical laboratory sciences by the AS...
      Speaker: Marc Davies, PhD , Stacie Chvatal, PhD
      Sponsored By: Axion BioSystems
      12
      SEP 21, 2023 | 8:00 AM
      Illicit Opioids: what you need to know
      Illicit Opioids: what you need to know
      As the opioid epidemic continues to claim lives and devastate families across the nation and world, we recognize September 21, 2023 as opioid awareness day. Opioids are analgesics with high...
      Speaker: Patrick Kyle
      Sponsored By: Abbott
      27
      MAR 08, 2023 | 7:30 AM
      Keynote Presentation: Improving Research Translation in Dementia: Humanized Mouse Models, Cognition and Imaging with Live Q&A
      Keynote Presentation: Improving Research Translation in Dementia:...
      Animal models present a unique opportunity to understand molecular mechanisms of pathological changes involved in cognitive dysfunction in neurological disorders. However, most of the work f...
      Speaker: Marco A.M. Prado, Pharm, MSc, PhD
      Presented at: Neuroscience Virtual Event Series 2023
      4
      MAR 08, 2023 | 6:00 AM
      Novel Tools for Drug Discovery in Neurodegenerative Diseases
      Novel Tools for Drug Discovery in Neurodegenerative Diseases
      Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Both diseases are characterized by abnormal aggregates in the brain, which incl...
      Speaker: Jacob McPhail, PhD
      Presented at: Neuroscience Virtual Event Series 2023
      3
      FEB 22, 2023 | 5:30 AM
      Bridging the Gap - How Human Microphysiological Systems Improve the Translatability of NASH Drug Discovery
      Bridging the Gap - How Human Microphysiological Systems Improve...
      Non-alcoholic fatty liver disease (NAFLD) is a spectrum of metabolic disorders affecting 25% of our global population. 20% of NAFLD patients go on to develop Non-alcoholic steatohepatitis (N...
      Speaker: Raul Silva
      Presented at: Drug Discovery & Development Virtual Event Series 2023
      2
      MAR 10, 2022 | 11:55 PM
      Characterizing Pathology-Inducing Protein Aggregates as Tools for Alzheimer's and Parkinson's Disease Models and Drug Discovery
      Characterizing Pathology-Inducing Protein Aggregates as Tools...
      Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Despite their debilitating effects and increasing prevalence in our society, no...
      Speaker: Jacob McPhail, PhD
      Presented at: Neuroscience Virtual Event Series 2022
      2 1
      MAR 09, 2022 | 8:00 AM
      Biosecurity for Genome Engineering: Safety First and the SeqScreen Solution for Functional Predictions
      Biosecurity for Genome Engineering: Safety First and the SeqScreen...
      Date: March 09, 2021 Time: 08:00am (PST), 11:00am (EST), 5:00pm (CEST) Bioengineering technologies hold enormous potential to solve many of our world’s pressing problems. However, they...
      Speaker: Todd Treangen, PhD , Krista Ternus, PhD, PMP , Beth Vitalis, PhD
      Sponsored By: Inscripta
      5
      FEB 23, 2022 | 11:55 PM
      Addressing Both Sides of the Coin - Microphysiological Systems to Better Predict Safety and Efficacy of Novel Therapies
      Addressing Both Sides of the Coin - Microphysiological Systems...
      Current drug discovery workflows are inefficient. 90% of therapeutic agents reaching clinical trials fail, predominantly because traditional laboratory experiments fail to adequately predict...
      Speaker: Audrey Dubourg, MSc, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2022
      3
      FEB 23, 2022 | 11:55 PM
      Development and Characterization of an In Vitro Integrated Organ Platform for the Evaluation of Pharmacokinetic and Toxicologic Effects of Drugs and Chemicals
      Development and Characterization of an In Vitro Integrated Organ...
      The quest for alternatives to animal safety testing has fueled the development, characterization, and validation of many new technologies. There have been advances in cell and tissue models...
      Speaker: James McKim, PhD
      Presented at: Drug Discovery & Development Virtual Event Series 2022
      3
      OCT 07, 2021 | 11:55 PM
      Neoantigen Vaccines for Personalized Immunotherapy
      Neoantigen Vaccines for Personalized Immunotherapy
      Summary: Cancer neoantigens are highly specific to the tumor, potently immunogenic and can be targeted by both vaccines and engineered cellular therapies. This talk will introduce the defini...
      Speaker: Yan Asmann, PhD
      Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
      1
      SEP 29, 2021 | 11:00 AM
      Automating culture and high-content imaging of 3D organoids for in vitro assessment of compound effects
      Automating culture and high-content imaging of 3D organoids for...
      Date: Septembr 29, 2021 Time: 11:00am (PDT), 2:00pm (EDT) 3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. While...
      Speaker: Oksana Sirenko, PhD
      Sponsored By: Molecular Devices
      9
      SEP 17, 2021 | 12:00 PM
      Developing better techniques for 3D culture and analysis.
      Developing better techniques for 3D culture and analysis.
      Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
      Speaker: Edwin Golez, M.S. , Bhaskar Mandavilli
      Sponsored By: Thermo Fisher Scientific/Gibco
      10 2
      SEP 08, 2021 | 12:00 AM
      Translating Pharmacomicrobiomics: From Microbiome Cloud Uncertainty to Pharmaceutical and Clinical Application(s)
      Translating Pharmacomicrobiomics: From Microbiome Cloud Uncertainty...
      The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
      Speaker: Ramy K. Aziz, PhD
      Presented at: Microbiology Week Virtual Event Series 2021
      1
      AUG 25, 2021 | 12:00 AM
      Characterizing Pathogenic Protein Aggregates for Utilization as Molecular Tools to Accelerate Neurodegenerative Disease Research
      Characterizing Pathogenic Protein Aggregates for Utilization as...
      Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Despite their debilitating effects and increasing prevalence in society, no cur...
      Speaker: Jacob McPhail, PhD
      Presented at: Neuroscience Virtual Event Series 2021
      Sponsored By: StressMarq Biosciences
      1
      JUN 02, 2021 | 12:00 AM
      Using genetically engineered preclinical models to study T cell therapy against solid tumors
      Using genetically engineered preclinical models to study T cell...
      Immune checkpoint therapy (ICT) is a front-line treatment for lung cancer; however, low mutational burden and ‘non-T cell inflamed’ signatures predict poor responses to ICT in ~5...
      Speaker: Leah Schmidt, PhD
      Presented at: Immuno-Oncology Virtual Event Series 2021
      3
      APR 15, 2021 | 8:00 AM
      Human Pluripotent Stem Cells as a Model for Neurodevelopmental Toxicity
      Human Pluripotent Stem Cells as a Model for Neurodevelopmental...
      Date: April 15, 2021 Time: 8:00am PST Stem cell’s unique properties confer them a multitude of potential applications in the fields of cellular therapy, disease modelling and drug scre...
      Speaker: Cláudia Miranda
      Sponsored By: Thermo Fisher Scientific/Gibco
      4
      FEB 10, 2021 | 12:00 AM
      Experimental design strategies in primate trials that embrace the clinical schema to enhance translation
      Experimental design strategies in primate trials that embrace...
      Primates have been essential in unlocking novel immune mechanisms that have driven development of groundbreaking new drugs in infectious disease and transplantation, amongst others related t...
      Speaker: Melanie L. Graham, MPH, PhD
      Presented at: Laboratory Animal Sciences Virtual Event Series 2021
      5
      DEC 03, 2020 | 4:30 PM
      An Iterative Approach to Structure-based in silico to in vivo Development of Combinatorial Anti-SARS-CoV-2 Therapy
      An Iterative Approach to Structure-based in silico to in vivo...
      This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
      Speaker: Garth Ehrlich, PhD, FAAAS
      Presented at: Coronavirus Series
      5
      OCT 08, 2020 | 10:00 AM
      The importance of liquid biopsy MSI for studying tumors and immunotherapy applications
      The importance of liquid biopsy MSI for studying tumors and immunotherapy...
      DATE: October 8, 2020 TIME: 1:00pm PDT Microsatellite instability (MSI) has evolved as a marker of potential hereditary cancer risk and is now a tissue agnostic immune biomarker with a broad...
      Speaker: Paul Walker, MD, FACP
      Sponsored By: Thermo Fisher Scientific - Applied Biosystems
      9
      SEP 30, 2020 | 12:00 AM
      Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
      Elucidation of remdesivir cytotoxicity pathways through genome-wide...
      The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
      Speaker: Minja Velimirovic, MSc, PhD Candidate
      Presented at: CRISPR Virtual Event Series 2020
      1
      SEP 23, 2020 | 1:30 PM
      Keynote Presentation: Starting at the source: tissue extracellular vesicles and Alzheimer's disease
      Keynote Presentation: Starting at the source: tissue extracellular...
      Extracellular vesicles (EVs) are lipid bilayer-delimited pieces of cells that are released from the plasma membrane as "ectosomes" and from the endosomal system as "exosomes.&...
      Speaker: Kenneth W. Witwer, PhD
      Presented at: Cell Biology Virtual Event Series 2020
      1
      SEP 10, 2020 | 7:30 AM
      Keynote Presentation: Discovery of a gene-microbiome interaction in lung cancer: lessons learned and future directions
      Keynote Presentation: Discovery of a gene-microbiome interaction...
      The selective pressure placed on the resident microbiota by local changes in the host environment – DNA damage, chronic inflammation, metabolic shifts, barrier damage, reduced immunosu...
      Speaker: K. Leigh Greathouse, PhD, MPH, MS, RD
      Presented at: Microbiology Week Virtual Event Series 2020
      3
    DEC 05, 2023 | 8:00 AM
    CGX10 Cell Isolation System:
    CGX10 Cell Isolation System:
    CGX10 Cell Isolation System: Introduction, Utility, and Assessment in a GMP-grade Environment for Multiparametric Cell Sorting A future of long-term, minimally toxic immunotherapy personaliz...
    Speaker: Jerry Barnhart , Manoja Eswara
    Sponsored By: Sony Biotechnology
    13
    NOV 07, 2023 | 10:00 AM
    Understanding the Mechanisms of Resistance in CAR T Immunotherapy for Lymphoma and Strategies to Overcome Them
    Understanding the Mechanisms of Resistance in CAR T Immunotherapy...
    In the last 5 years, the US Food and Drug Administration has approved 4 anti-CD19 chimeric antigen receptor T cell (CART19) products for relapsed/refractory B cell lymphomas and leukemia. Ho...
    Speaker: Marco Ruella
    Sponsored By: Beckman Coulter Life Sciences
    22
    SEP 28, 2023 | 7:00 AM
    Optimizing CAR structures to enhance efficacy in solid tumours; moving from linear to lateral architectures.
    Optimizing CAR structures to enhance efficacy in solid tumours;...
    Webinars will be available for unlimited on-demand viewing after live event. Labroots is approved as a provider of continuing education programs in the clinical laboratory sciences by the AS...
    Speaker: Marc Davies, PhD , Stacie Chvatal, PhD
    Sponsored By: Axion BioSystems
    12
    SEP 21, 2023 | 8:00 AM
    Illicit Opioids: what you need to know
    Illicit Opioids: what you need to know
    As the opioid epidemic continues to claim lives and devastate families across the nation and world, we recognize September 21, 2023 as opioid awareness day. Opioids are analgesics with high...
    Speaker: Patrick Kyle
    Sponsored By: Abbott
    27
    MAR 08, 2023 | 7:30 AM
    Keynote Presentation: Improving Research Translation in Dementia: Humanized Mouse Models, Cognition and Imaging with Live Q&A
    Keynote Presentation: Improving Research Translation in Dementia:...
    Animal models present a unique opportunity to understand molecular mechanisms of pathological changes involved in cognitive dysfunction in neurological disorders. However, most of the work f...
    Speaker: Marco A.M. Prado, Pharm, MSc, PhD
    Presented at: Neuroscience Virtual Event Series 2023
    4
     
     
  • MAR 08, 2023 | 6:00 AM
    Novel Tools for Drug Discovery in Neurodegenerative Diseases
    Novel Tools for Drug Discovery in Neurodegenerative Diseases
    Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Both diseases are characterized by abnormal aggregates in the brain, which incl...
    Speaker: Jacob McPhail, PhD
    Presented at: Neuroscience Virtual Event Series 2023
    3
    FEB 22, 2023 | 5:30 AM
    Bridging the Gap - How Human Microphysiological Systems Improve the Translatability of NASH Drug Discovery
    Bridging the Gap - How Human Microphysiological Systems Improve...
    Non-alcoholic fatty liver disease (NAFLD) is a spectrum of metabolic disorders affecting 25% of our global population. 20% of NAFLD patients go on to develop Non-alcoholic steatohepatitis (N...
    Speaker: Raul Silva
    Presented at: Drug Discovery & Development Virtual Event Series 2023
    2
    MAR 10, 2022 | 11:55 PM
    Characterizing Pathology-Inducing Protein Aggregates as Tools for Alzheimer's and Parkinson's Disease Models and Drug Discovery
    Characterizing Pathology-Inducing Protein Aggregates as Tools...
    Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Despite their debilitating effects and increasing prevalence in our society, no...
    Speaker: Jacob McPhail, PhD
    Presented at: Neuroscience Virtual Event Series 2022
    2 1
    MAR 09, 2022 | 8:00 AM
    Biosecurity for Genome Engineering: Safety First and the SeqScreen Solution for Functional Predictions
    Biosecurity for Genome Engineering: Safety First and the SeqScreen...
    Date: March 09, 2021 Time: 08:00am (PST), 11:00am (EST), 5:00pm (CEST) Bioengineering technologies hold enormous potential to solve many of our world’s pressing problems. However, they...
    Speaker: Todd Treangen, PhD , Krista Ternus, PhD, PMP , Beth Vitalis, PhD
    Sponsored By: Inscripta
    5
    FEB 23, 2022 | 11:55 PM
    Addressing Both Sides of the Coin - Microphysiological Systems to Better Predict Safety and Efficacy of Novel Therapies
    Addressing Both Sides of the Coin - Microphysiological Systems...
    Current drug discovery workflows are inefficient. 90% of therapeutic agents reaching clinical trials fail, predominantly because traditional laboratory experiments fail to adequately predict...
    Speaker: Audrey Dubourg, MSc, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2022
    3
     
     
  • FEB 23, 2022 | 11:55 PM
    Development and Characterization of an In Vitro Integrated Organ Platform for the Evaluation of Pharmacokinetic and Toxicologic Effects of Drugs and Chemicals
    Development and Characterization of an In Vitro Integrated Organ...
    The quest for alternatives to animal safety testing has fueled the development, characterization, and validation of many new technologies. There have been advances in cell and tissue models...
    Speaker: James McKim, PhD
    Presented at: Drug Discovery & Development Virtual Event Series 2022
    3
    OCT 07, 2021 | 11:55 PM
    Neoantigen Vaccines for Personalized Immunotherapy
    Neoantigen Vaccines for Personalized Immunotherapy
    Summary: Cancer neoantigens are highly specific to the tumor, potently immunogenic and can be targeted by both vaccines and engineered cellular therapies. This talk will introduce the defini...
    Speaker: Yan Asmann, PhD
    Presented at: Cancer Research & Oncology Week Virtual Event Series 2021
    1
    SEP 29, 2021 | 11:00 AM
    Automating culture and high-content imaging of 3D organoids for in vitro assessment of compound effects
    Automating culture and high-content imaging of 3D organoids for...
    Date: Septembr 29, 2021 Time: 11:00am (PDT), 2:00pm (EDT) 3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. While...
    Speaker: Oksana Sirenko, PhD
    Sponsored By: Molecular Devices
    9
    SEP 17, 2021 | 12:00 PM
    Developing better techniques for 3D culture and analysis.
    Developing better techniques for 3D culture and analysis.
    Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
    Speaker: Edwin Golez, M.S. , Bhaskar Mandavilli
    Sponsored By: Thermo Fisher Scientific/Gibco
    10 2
    SEP 08, 2021 | 12:00 AM
    Translating Pharmacomicrobiomics: From Microbiome Cloud Uncertainty to Pharmaceutical and Clinical Application(s)
    Translating Pharmacomicrobiomics: From Microbiome Cloud Uncertainty...
    The Human Microbiome Project was conceived almost 15 years ago, as an extension of the Human Genome Project, to explore the diversity of human-associated microorganisms at multiple body site...
    Speaker: Ramy K. Aziz, PhD
    Presented at: Microbiology Week Virtual Event Series 2021
    1
     
     
  • AUG 25, 2021 | 12:00 AM
    Characterizing Pathogenic Protein Aggregates for Utilization as Molecular Tools to Accelerate Neurodegenerative Disease Research
    Characterizing Pathogenic Protein Aggregates for Utilization as...
    Alzheimer’s and Parkinson’s diseases (AD, PD) are the two most common neurodegenerative disorders. Despite their debilitating effects and increasing prevalence in society, no cur...
    Speaker: Jacob McPhail, PhD
    Presented at: Neuroscience Virtual Event Series 2021
    Sponsored By: StressMarq Biosciences
    1
    JUN 02, 2021 | 12:00 AM
    Using genetically engineered preclinical models to study T cell therapy against solid tumors
    Using genetically engineered preclinical models to study T cell...
    Immune checkpoint therapy (ICT) is a front-line treatment for lung cancer; however, low mutational burden and ‘non-T cell inflamed’ signatures predict poor responses to ICT in ~5...
    Speaker: Leah Schmidt, PhD
    Presented at: Immuno-Oncology Virtual Event Series 2021
    3
    APR 15, 2021 | 8:00 AM
    Human Pluripotent Stem Cells as a Model for Neurodevelopmental Toxicity
    Human Pluripotent Stem Cells as a Model for Neurodevelopmental...
    Date: April 15, 2021 Time: 8:00am PST Stem cell’s unique properties confer them a multitude of potential applications in the fields of cellular therapy, disease modelling and drug scre...
    Speaker: Cláudia Miranda
    Sponsored By: Thermo Fisher Scientific/Gibco
    4
    FEB 10, 2021 | 12:00 AM
    Experimental design strategies in primate trials that embrace the clinical schema to enhance translation
    Experimental design strategies in primate trials that embrace...
    Primates have been essential in unlocking novel immune mechanisms that have driven development of groundbreaking new drugs in infectious disease and transplantation, amongst others related t...
    Speaker: Melanie L. Graham, MPH, PhD
    Presented at: Laboratory Animal Sciences Virtual Event Series 2021
    5
    DEC 03, 2020 | 4:30 PM
    An Iterative Approach to Structure-based in silico to in vivo Development of Combinatorial Anti-SARS-CoV-2 Therapy
    An Iterative Approach to Structure-based in silico to in vivo...
    This drug development program is designed to create a family of broad-spectrum, pan-coronaviral drugs that respectively inhibit multiple key enzymes required for viral replication. By target...
    Speaker: Garth Ehrlich, PhD, FAAAS
    Presented at: Coronavirus Series
    5
     
     
  • OCT 08, 2020 | 10:00 AM
    The importance of liquid biopsy MSI for studying tumors and immunotherapy applications
    The importance of liquid biopsy MSI for studying tumors and immunotherapy...
    DATE: October 8, 2020 TIME: 1:00pm PDT Microsatellite instability (MSI) has evolved as a marker of potential hereditary cancer risk and is now a tissue agnostic immune biomarker with a broad...
    Speaker: Paul Walker, MD, FACP
    Sponsored By: Thermo Fisher Scientific - Applied Biosystems
    9
    SEP 30, 2020 | 12:00 AM
    Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
    Elucidation of remdesivir cytotoxicity pathways through genome-wide...
    The adenosine analogue remdesivir has emerged as a front-line antiviral treatment for SARS-CoV-2, with preliminary evidence that it reduces the duration and severity of illness. Prior clinic...
    Speaker: Minja Velimirovic, MSc, PhD Candidate
    Presented at: CRISPR Virtual Event Series 2020
    1
    SEP 23, 2020 | 1:30 PM
    Keynote Presentation: Starting at the source: tissue extracellular vesicles and Alzheimer's disease
    Keynote Presentation: Starting at the source: tissue extracellular...
    Extracellular vesicles (EVs) are lipid bilayer-delimited pieces of cells that are released from the plasma membrane as "ectosomes" and from the endosomal system as "exosomes.&...
    Speaker: Kenneth W. Witwer, PhD
    Presented at: Cell Biology Virtual Event Series 2020
    1
    SEP 10, 2020 | 7:30 AM
    Keynote Presentation: Discovery of a gene-microbiome interaction in lung cancer: lessons learned and future directions
    Keynote Presentation: Discovery of a gene-microbiome interaction...
    The selective pressure placed on the resident microbiota by local changes in the host environment – DNA damage, chronic inflammation, metabolic shifts, barrier damage, reduced immunosu...
    Speaker: K. Leigh Greathouse, PhD, MPH, MS, RD
    Presented at: Microbiology Week Virtual Event Series 2020
    3
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