Transcription is the first step in gene expression in which genetic information is copied from a DNA to an RNA format. Transcription is controlled by proteins known as transcription factors that regulate the expression of genes.
Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types, yet its mechanism remains unclear. By using a multi-omics approach, overlay of multiple spa...
RNA-based therapeutics are transforming medicine, but scaling production efficiently remains a challenge, particularly the cost-intensive in vitro transcription (IVT) step. Join this webinar...
Engineered immune cell therapies offer the promise of more tailored interventions than traditional systemic checkpoint blockades, but so far remain ineffective across the majority of clinica...
CRISPR-Cas9 has been widely adapted for use in transcriptional modulation and epigenetic engineering with deactivated Cas9 (dCas9) systems to enable CRISPR interference (CRISPRi) and CRISPR...
Double-stranded RNA (dsRNA) is a well-recognized byproduct of in vitro transcription that poses significant challenges for the use of synthetic mRNA in research and therapeutic applications....
Ebola virus executes its replication cycle through a tightly orchestrated sequence of events, but the host factors that govern the timing of these steps have remained poorly defined. In this...
Aging is accompanied by widespread epigenetic reprogramming, including the loss of heterochromatin and altered chromatin-associated processes. These changes compromise transcriptional precis...
Immune checkpoint blockade (ICB) targeting T cells has enhanced clinical outcomes in patients with renal and bladder cancers; however, response rates remain limited, particularly in cases of...
The MAF bZIP Transcription Factor G (MAFG) is a member of the small MAF family of proteins. Previously, we have shown that miRNA-29 suppresses melanoma development, at least in part, by repr...
As sessile organisms, plants are incredibly mindful of their time. As a result, they extensively regulate cellular and physiological processes through a combination of circadian (anticipator...
Stem cells, particularly Induced Pluripotent Stem Cells (iPSCs), are becoming essential tools in scientific research, from drug discovery to disease modeling. As the scientific community shi...
In part 2 of this webinar, Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, will reveal new data that illustrates how the Hodges Lab is utilizing the 6-base ge...
To enhance productivity in research laboratories conducting genomic studies, automation techniques along with rapid workflows are encouraged. Here, we discuss gene expression analysis by rev...
Advances in proteomics and mass spectrometry enable the study of limited cell populations such as performing mouse models. Low-protein load studies often requires two steps to perform differ...
Engineered immune cell therapies offer the promise of more tailored interventions than traditional systemic checkpoint blockades, but so far remain ineffective across the majority of clinica...
Real-time reverse transcription PCR analysis of RNA expression in normal and diseased states is a fundamental technique used in research workflows. Immortalized and primary cells are often u...
This webinar is designed to explore the fundamental characteristics of reverse transcriptases and the essential factors that play a pivotal role in achieving high-quality cDNA synthesis from...
Organisms sense and respond to changes in the environment through signal transduction pathways. Pathways like highly conserved Mitogen-Activated Protein Kinase (MAPK) pathways are composed o...
Human respiratory syncytial virus (hRSV) infection is a significant global health and economic burden. Lower respiratory tract hRSV infections predominantly affect young children, the elderl...
Unlocking the potential of mRNA technology is revolutionizing medicine and biotechnology. Solid-phase in vitro transcription enables scalability and automation, making it a valuable tool for...
Genomics, epigenomics and transcriptomics are often thought of as independent fields, but in our clinical practice we use them combined to increase diagnostic yield both for constitutional a...
The recognition of mRNA molecules as a transformative class of therapeutic drugs has soared, particularly with the development of COVID 19 mRNA vaccines. The cancer treatment landscape is si...
Deciphering somatic mosaicism in healthy tissues and clonal diversity in tumors necessitates single-cell analysis. High-quality genomic and transcriptomic data at the single-cell level depen...
mRNA‑based products are rapidly growing in the biotherapeutics space. Important considerations need to be made to develop a process for mRNA synthesis that consistently generates high‑yield...
Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types, yet its mechanism remains unclear. By using a multi-omics approach, overlay of multiple spa...
RNA-based therapeutics are transforming medicine, but scaling production efficiently remains a challenge, particularly the cost-intensive in vitro transcription (IVT) step. Join this webinar...
Engineered immune cell therapies offer the promise of more tailored interventions than traditional systemic checkpoint blockades, but so far remain ineffective across the majority of clinica...
CRISPR-Cas9 has been widely adapted for use in transcriptional modulation and epigenetic engineering with deactivated Cas9 (dCas9) systems to enable CRISPR interference (CRISPRi) and CRISPR...
Double-stranded RNA (dsRNA) is a well-recognized byproduct of in vitro transcription that poses significant challenges for the use of synthetic mRNA in research and therapeutic applications....
Ebola virus executes its replication cycle through a tightly orchestrated sequence of events, but the host factors that govern the timing of these steps have remained poorly defined. In this...
Aging is accompanied by widespread epigenetic reprogramming, including the loss of heterochromatin and altered chromatin-associated processes. These changes compromise transcriptional precis...
Immune checkpoint blockade (ICB) targeting T cells has enhanced clinical outcomes in patients with renal and bladder cancers; however, response rates remain limited, particularly in cases of...
The MAF bZIP Transcription Factor G (MAFG) is a member of the small MAF family of proteins. Previously, we have shown that miRNA-29 suppresses melanoma development, at least in part, by repr...
As sessile organisms, plants are incredibly mindful of their time. As a result, they extensively regulate cellular and physiological processes through a combination of circadian (anticipator...
Stem cells, particularly Induced Pluripotent Stem Cells (iPSCs), are becoming essential tools in scientific research, from drug discovery to disease modeling. As the scientific community shi...
In part 2 of this webinar, Dr. Emily Hodges, assistant professor of biochemistry at Vanderbilt University, will reveal new data that illustrates how the Hodges Lab is utilizing the 6-base ge...
To enhance productivity in research laboratories conducting genomic studies, automation techniques along with rapid workflows are encouraged. Here, we discuss gene expression analysis by rev...
Advances in proteomics and mass spectrometry enable the study of limited cell populations such as performing mouse models. Low-protein load studies often requires two steps to perform differ...
Engineered immune cell therapies offer the promise of more tailored interventions than traditional systemic checkpoint blockades, but so far remain ineffective across the majority of clinica...
Real-time reverse transcription PCR analysis of RNA expression in normal and diseased states is a fundamental technique used in research workflows. Immortalized and primary cells are often u...
This webinar is designed to explore the fundamental characteristics of reverse transcriptases and the essential factors that play a pivotal role in achieving high-quality cDNA synthesis from...
Organisms sense and respond to changes in the environment through signal transduction pathways. Pathways like highly conserved Mitogen-Activated Protein Kinase (MAPK) pathways are composed o...
Human respiratory syncytial virus (hRSV) infection is a significant global health and economic burden. Lower respiratory tract hRSV infections predominantly affect young children, the elderl...
Unlocking the potential of mRNA technology is revolutionizing medicine and biotechnology. Solid-phase in vitro transcription enables scalability and automation, making it a valuable tool for...
Genomics, epigenomics and transcriptomics are often thought of as independent fields, but in our clinical practice we use them combined to increase diagnostic yield both for constitutional a...
The recognition of mRNA molecules as a transformative class of therapeutic drugs has soared, particularly with the development of COVID 19 mRNA vaccines. The cancer treatment landscape is si...
Deciphering somatic mosaicism in healthy tissues and clonal diversity in tumors necessitates single-cell analysis. High-quality genomic and transcriptomic data at the single-cell level depen...
mRNA‑based products are rapidly growing in the biotherapeutics space. Important considerations need to be made to develop a process for mRNA synthesis that consistently generates high‑yield...
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