FEB 04, 2019 12:33 PM PST

Obesity-Related Cancers in Millennials

WRITTEN BY: Amy Loriaux

In a recent report out of The Lancet: Public Health, published by Dr. Ahmedin Jemal, Ph.D., and colleagues from the American Cancer Society, it was shown that millennials are twice as likely as the generations before them to develop obesity-related cancers. These cancers, such as colorectal, kidney and pancreatic cancers are increasing at an alarming rate in this population.

Photo source: UnSplash.com

The study used incidence data for invasive cancers among people aged 25–84 years diagnosed from 1995 to 2014. They looked at the incidence rate for 30 types of cancer, including 12 that are linked to obesity. Cancer diagnoses increased for 6 of 12 obesity-related cancers (multiple myeloma, colorectal, uterine corpus, gallbladder, kidney, and pancreatic cancer) in young adults, aged 25–49 years, with steeper rises in successively younger generations.  

The reason(s) behind these data are yet to be elucidated, yet there are some theories and a number of questions. First off, what is the link between obesity and cancer in the first place? According to the American Cancer Society, obese individuals can have chronic low-levels of inflammation. That is, they are undergoing inflammation constantly. This chronic inflammation can go on to damage cellular DNA, which can lead to cancer. Furthermore, other obesity-related diseases could lead to cancer on their own. Another link is that obese individuals have more fat tissue and fat tissue produces excess amounts of estrogen. These high levels have been associated with increased risks of breast, endometrial, ovarian, and some other cancers. 

There are several other biological theories linking obesity to cancer. But what about the link to the increase in obese-related cancers in young people? One potential mechanism could be that individuals born during the 1980s (the beginning of the millennial births) experienced potentially key developmental life stages for obesity during the beginning phases of the "obesity epidemic". Earlier and longer-lasting exposure to excess fat at such a young age could potentially increase the chances of becoming obese as they age, and then going on to developing obesity-related cancers. 

Photo source: UnSplash.com

The recent report also discussed how rates for the development of obese-related cancer in young people today are similar to the rates of cancer development in older generations. More alarmingly, the report also states that this rate is climbing for younger and younger adults. In adults aged 30 years and older in the USA, excess bodyweight could account for up to 60% of all endometrial cancers, 36% of gallbladder cancers, 33% of kidney cancers, 17% of pancreatic cancers, and 11% of multiple myelomas according to another report in 2014.

The current report concluded that this increase in obesity-related cancers in young people has significant practical public health implications, especially for health-care providers and policymakers. As the millennials age, will they be more at risk for certain cancers that the older generation of today? They advise that we ramp up our efforts to screen children and adults for obesity and body-weight indexes. According to Dr. Jemel, "The future burden of these cancers could worsen as younger cohorts age, potentially halting or reversing the progress achieved in reducing cancer mortality over the past several decades".

Sources: The Lancet: Public Healthwww.cancer.org,  International Journal of Obesity and Metabolic DisordersCA A Cancer Journal For Clinicians, Forbes.com

About the Author
  • I currently work at a small CRO involved in clinical trial management.
You May Also Like
AUG 12, 2021
Cancer
Promising Drug Target Identified for Deadly Ovarian Cancer
AUG 12, 2021
Promising Drug Target Identified for Deadly Ovarian Cancer
Scientists at the University of Alabama at Birmingham have identified a gene called DOT1L for its role in progressing th ...
AUG 13, 2021
Cancer
Ultrasound Triggers Immunotherapy to Destroy Tumors
AUG 13, 2021
Ultrasound Triggers Immunotherapy to Destroy Tumors
An immunotherapy engineered to be triggered by ultrasound beams significantly slows the growth of cancerous tumors in mi ...
AUG 19, 2021
Cancer
Japanese Berry Vine Could Treat Lung Cancer
AUG 19, 2021
Japanese Berry Vine Could Treat Lung Cancer
A berry-producing vine in Japan has shown promise in mouse models for treating lung cancer. The corresponding study was ...
SEP 02, 2021
Cancer
When Cholesterol Doesn't Kill Cancer, it Makes it Stronger!
SEP 02, 2021
When Cholesterol Doesn't Kill Cancer, it Makes it Stronger!
High cholesterol is associated with an increased risk of several types of cancer, and cancer patients with high choleste ...
OCT 21, 2021
Cancer
Exercise: A Secret Weapon to Combat Prostate Cancer?
OCT 21, 2021
Exercise: A Secret Weapon to Combat Prostate Cancer?
Exercise oncology is an evolving science that considers the addition of physical activity regimens to the treatment ...
NOV 09, 2021
Immunology
Wikipedia, but Make It Immune Cells
NOV 09, 2021
Wikipedia, but Make It Immune Cells
Scientists have established the first searchable database of complex immune data, providing the foundations for a new er ...
Loading Comments...