JUN 24, 2019 9:55 PM PDT

Preventing inflammation to manage cancer

New research led by Dipak Panigrahy, MD, and Allison Gartung, PhD, of the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) suggests that traditional cancer treatments may be doing more harm than good – particularly when it comes to inflammation and new tumor growth. The study was published online in The Journal of Clinical Investigation.

"Cancer therapy is a double-edged sword, as dying cancer cells can trigger inflammation and promote the growth of microscopic cancerous cells," said Panigrahy. "Surgery, chemotherapy and radiation can all induce the body's inflammatory/immunosuppressive injury response. Even anesthetics can impair the resolution of inflammation."

The idea is that physiologic stress, which could come in any of the forms that Panigrahy mentions above, can trigger microscopic cancers to grow into new tumors. In order to prevent that, Panigrahy and colleagues thought to try blocking of the inflammatory cascade and/or accelerating the resolution of inflammation.

One method through which they tried this process was via administering a nonsteroidal anti-inflammatory drug called ketorolac before surgery; they also tired administering preoperative resolvins -- naturally occurring anti-inflammatory factors that are made by the human body. Both of these processes eliminated the spread of cancer cells in several tumor-resection models, meaning that they have potential for improving anti-inflammatory cancer treatments in the future.

Managing inflammation could help patients with cancer. Photo: Pixabay

While the researchers conducted their study on animal models, not humans, co-author Vikas P. Sukhatme, MD, ScD, and Dean of Emory University School of Medicine, says "Collectively, our findings suggest a potential paradigm shift in our approach to resectable cancers. Clinical trials are now urgently needed to validate these animal studies."

Sources: Science Daily, The Journal of Clinical Investigation

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
APR 16, 2020
Cancer
APR 16, 2020
This drug hopes to prevent cancer relapse
A report published in Nature Communications highlights findings from a study showing that the experimental drug, Qu ...
APR 19, 2020
Cancer
APR 19, 2020
Discovery of new biomarker detects urological cancer
New hope for the detection of urological cancers has been published in a study in the Journal of Extracellular Vesicles. ...
MAY 02, 2020
Drug Discovery & Development
MAY 02, 2020
Glioblastoma Treatment Using Schizophrenic Drug Plus Radiation
A therapeutic used for the treatment of schizophrenia could be a gateway for targeting glioblastoma, one of the deadlies ...
MAY 11, 2020
Cancer
MAY 11, 2020
Are antihistamines helpful for cancer?
Research recently published in the research journal Allergy suggests that a common antihistamine could improve survival ...
MAY 10, 2020
Drug Discovery & Development
MAY 10, 2020
Antiviral Drug Treats Naso-Pharyngeal Cancer
Scientists at Hong Kong Baptist University (HKBU) developed a novel anti-Epstein-Barr virus (EBV) drug that can shrink t ...
MAY 29, 2020
Cancer
MAY 29, 2020
What can we do about drug-induced tetraploidy in cancer cells?
A paper published in the journal Trends in Cancer describes how cancer therapies sometimes fuel genetic changes in cells ...
Loading Comments...