APR 19, 2020 10:56 AM PDT

Discovery of new biomarker detects urological cancer

New hope for the detection of urological cancers has been published in a study in the Journal of Extracellular Vesicles. The study comes from researchers from Ghent University in Belgium and the University of Turku in Finland. Urological cancers refer to prostate, bladder and kidney cancers.

The researchers have developed a new approach using extracellular vesicles as biomarkers in order to detect cancer. Extracellular vesicles are microscopic vesicles that are released by cancer cells into biological fluids like urine. Until now, the problem has been that the scientific community has been lacking an effective method for separating extracellular vesicles from urine. But these European researchers have come up with a novel solution.

As the authors write in their study, “Urine is considered an ideal proximal fluid for the study of extracellular vesicles in urological cancers due to its direct contact with the urogenital system. We demonstrate that density-based fractionation of urine by bottom-up Optiprep density gradient centrifugation separates extracellular vesicles and soluble proteins with high specificity and repeatability.”

When they applied their method to urine samples from patients with prostate, bladder and kidney cancer, they found that extracellular vesicles in urine carry protein signatures that are particular to those various urological cancers.

This development is huge for the world of urological cancer detection. Their method offers a promising new technique for isolating extracellular vesicles so that they can be used in patient diagnostics and treatment and hopefully improve early detection rates.

Sources: Journal of Extracellular Vesicles, Science Daily

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
MAR 05, 2020
Health & Medicine
MAR 05, 2020
Colorectal Cancers on the Rise in Younger People
Colorectal cancer rates are rising among young Americans, according to the most recent report from the American Cancer S ...
MAR 15, 2020
Cancer
MAR 15, 2020
The racism behind cancer
Researchers from the University of Colorado Cancer Center have made strides in understanding the reasons behind disparit ...
APR 23, 2020
Cancer
APR 23, 2020
Dual Inhibition from One Chemotherapy
Acute Myeloid Leukemia, or AML, is an aggressive blood cancer with a poor 5-year prognosis. The primary targets of chemo ...
APR 28, 2020
Cancer
APR 28, 2020
Is a multi-cancer detection blood test safe for women?
Earlier detection is essential in order to reduce deaths caused by cancer. A new study, DETECT-A (Detecting cancers Earl ...
MAY 04, 2020
Cancer
MAY 04, 2020
A Retroactive Study Finds an Immunotherapy Effective as a Third-Line Therapy
Cancer is a particularly persistent disease. Many therapies are composed of one or more different treatments. These trea ...
MAY 18, 2020
Cancer
MAY 18, 2020
The threat of climate change extends to cancer progression
A study appearing in the American Cancer Society’s CA: A Cancer Journal for Clinicians argues that climate change ...
Loading Comments...