MAY 04, 2020 11:52 AM PDT

A Retroactive Study Finds an Immunotherapy Effective as a Third-Line Therapy

WRITTEN BY: Jasper Cantrell

Cancer is a particularly persistent disease. Many therapies are composed of one or more different treatments. These treatments are referred to as first-line, second-line, and so on. First-line treatments are often the best available option, with second line treatments being the next best option should the first fail to induce full remission. Ramucirumab is an example of second-line treatment in gastric and other cancers. Recently it has been increasingly used as a third-line treatment or later. There is a lack of research in its effectiveness as a third-line treatment, and a group from Japan decided to retroactively investigate.

Gastric cancer is the third leading cause of cancer-related deaths in the world. Ramucirumab was initially approved for the treatment of advanced gastric cancer, and this is where the group started. They gathered a sample of fifty-one patients with a variety of advanced gastric cancers, forty-four of which having been treated at least twice before. They began treating all patients with ramucirumab and followed the results.

Of the fifty-one patients, forty-seven patients had to halt their ramucirumab treatments due to cancer progression or other adverse events. Out of the sample, there was a 17% disease control rate and a 2% response rate. There were a few patients who showed no effect on treatment. Thirty-eight of the patients had adverse effects during the trial, however, no patients had fatal reactions.

The primary variables the group used to determine the success or failure of this study were progression-free survival (PFS) and overall survival (OS) of the patients in the trial. Previous works had ramucirumab achieve a PFS of 2.1 and 1.6, with an OS of 5.2 and 7.3. This group's findings were similar, with a PFS of 1.8 and an OS of 5.1. The group goes on to postulate that these numbers are identical to figures from second-line treatments. Any differences in the numbers are likely due to the selectivity of the patients' treatments.

Ramucirumab maintains its effectiveness as a third-line treatment with little to no difference in PFS or OS. The available options for treatment over the years have increased, with many new chemotherapies and immunotherapies available. This has led ramucirumab to be pushed to a third-line treatment. The group concludes that ramucirumab is still valid as a third-line treatment for advanced gastric cancers, concluding "Ramucirumab monotherapy demonstrates acceptable efficacy and feasibility as third- or later-line treatment for AGC. We consider physicians might choose this therapy as a salvage-line treatment option for AGC refractory to the standard therapies."

Sources: Journal of Clinical Oncology, OncLive TV
 

About the Author
  • Hey everyone! My name is Jasper and, considering I am pretty new here to Labroots, I figured I would introduce myself. I received my bachelor’s from the University of California at Riverside back in 2016. I started off my career a few years ago with a job at a University over in New York, before moving over into the industry. I'm happy to be writing content for Labroots, and I hope you enjoy it!
You May Also Like
SEP 18, 2020
Coronavirus
How Coronavirus Spread in the US and Europe
SEP 18, 2020
How Coronavirus Spread in the US and Europe
Researchers are beginning to examine how the world's response to the pandemic virus SARS-CoV-2 went wrong, and right ...
OCT 14, 2020
Cancer
Using Plasma Scalpels with Chemotherapy Against Brain Cancer
OCT 14, 2020
Using Plasma Scalpels with Chemotherapy Against Brain Cancer
Cold atmospheric plasma is a relatively new technique that utilizes a tool that generates a sort of plasma scalpel, exce ...
NOV 09, 2020
Genetics & Genomics
Potential Problems with Liquid Biopsies
NOV 09, 2020
Potential Problems with Liquid Biopsies
Liquid biopsies are tests that look for biomarkers in the blood, which can help inform the treatment of cancer. The tool ...
NOV 19, 2020
Cancer
New technique to synthesize phenazines offers hope for cancer treatments
NOV 19, 2020
New technique to synthesize phenazines offers hope for cancer treatments
Research from Tokyo University of Science investigators highlights new accomplishments in the fight against cancer. The ...
NOV 20, 2020
Cancer
How does tissue geometry influence cancer cellular migration?
NOV 20, 2020
How does tissue geometry influence cancer cellular migration?
A team of researchers led by UC Santa Barbara's Distinguished Professor Denise Montell has recently published new fi ...
DEC 01, 2020
Cancer
The price tag of prostate cancer treatment
DEC 01, 2020
The price tag of prostate cancer treatment
New research published in The Journal of Urology from the Official Journal of the American Urological Association&n ...
Loading Comments...