SEP 02, 2020 9:48 AM PDT

Does Adjuvant Chemotherapy Really Help in a Rare Signet-ring Cell Carcinoma

WRITTEN BY: Jasper Cantrell

For many rare diseases, there is a lack of a “standard” treatment options. This is more prevalent in diverse diseases like cancer, which has hundreds of types and subtypes. One rare type of colorectal cancer, signet-ring cell carcinoma, was the subject of a new study evaluating whether or not adjuvant therapy after surgery was effective.

A team from the First Hospital of Jilin University in China wanted to know if chemotherapy was necessary after tumor-removal surgery. The team notes some studies that there is conflicting evidence supporting adjuvant chemotherapy. Considering the high expense of chemotherapy, the team wanted to make sure patients were not spending even more on unnecessary treatment.

Their study revolved around analyzing signet-ring cell carcinoma patients from the SEER database to see how effective adjuvant chemotherapy was. This database covered a large percent of the North American population, and so should be a good representation of the population. In the end, they had a balanced dataset of patients who were treated with or without adjuvant chemotherapy (chemotherapy after surgery).

The data from the SEER database was pretty clear that those patients who were given the chemotherapy had a stronger overall survival rate than those who weren’t. The adjuvant chemotherapy nearly doubled the chances of survival compared to no adjuvant chemotherapy.  

If you followed common sense, you might also conclude that chemotherapy should help get rid of cancer. However, chemotherapy has many detrimental aspects to it, from toxic side-effects to sheer cost. The conflicting evidence has prevented a “standard” treatment for signet-ring cell carcinoma. The team notes that another study, one who took data from a large patient group over 20 years, agrees with this study’s results. Considering the clear positive correlation between survival and chemotherapy in this work, I would say evidence continues to support the pro-chemotherapy side.

The study concludes, “In conclusion, our results have shown that stage II/III colorectal SRCC can gain survival benefit from postoperative adjuvant chemotherapy. This is a large population-based study to discuss adjuvant chemotherapy for patients with localized colorectal SRCC, and our present findings might be of significance for disease management and future prospective researches.”

Sources: Nature Scientific Reports, OncLiveTV

About the Author
  • Hey everyone! My name is Jasper and, considering I am pretty new here to Labroots, I figured I would introduce myself. I received my bachelor’s from the University of California at Riverside back in 2016. I started off my career a few years ago with a job at a University over in New York, before moving over into the industry. I'm happy to be writing content for Labroots, and I hope you enjoy it!
You May Also Like
APR 11, 2021
Genetics & Genomics
Trial Shows Personalized Cancer Vaccines are Safe
APR 11, 2021
Trial Shows Personalized Cancer Vaccines are Safe
Vaccines are mostly known as tools to prevent illness. But cancer vaccines are a bit different, and aim to treat existin ...
APR 05, 2021
Cancer
Introducing DeepTCR, the deep-learning software for T-cell receptor sequencing data
APR 05, 2021
Introducing DeepTCR, the deep-learning software for T-cell receptor sequencing data
A team from the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center is introdu ...
MAY 24, 2021
Health & Medicine
How do healthcare insurance disruptions affect access and affordability to care?
MAY 24, 2021
How do healthcare insurance disruptions affect access and affordability to care?
Have you ever been in between health insurance coverage and pushed off receiving healthcare that you needed? According t ...
JUN 07, 2021
Cancer
Inflammatory-rich diet associated with greater risk of developing breast cancer
JUN 07, 2021
Inflammatory-rich diet associated with greater risk of developing breast cancer
A breakthrough study soon to be presented at NUTRITION 2021 LIVE ONLINE later this week reports that women who main ...
JUN 11, 2021
Cell & Molecular Biology
Bad Fat in the Tumor Microenvironment May Disrupt Killer T Cells
JUN 11, 2021
Bad Fat in the Tumor Microenvironment May Disrupt Killer T Cells
The immune system can detect and destroy pathogenic and cancerous cells, but sometimes those dangerous cells can evade t ...
JUN 27, 2021
Cancer
Are e-cigarettes actually helpful for smoking cessation?
JUN 27, 2021
Are e-cigarettes actually helpful for smoking cessation?
New research published in The Lancet Public Health reports on a study that looked at interventions targeting e-cigarette ...
Loading Comments...