NOV 11, 2020 8:39 AM PST

A New CDK Inhibitor Could Help with Unresponsive Liver Cancer

WRITTEN BY: Jasper Cantrell

Amongst the most common targets of anti-cancer drugs are small regulatory molecules called cyclin-dependent kinases (CDKs). In humans, several of these proteins regulate the cell cycle, a critical process in cellular replication, and interruption of anyone can set the cell into self-destruct mode.

Many successful chemotherapy treatments center around inhibiting one or more of these CDKs. Cancer is constantly growing, and therefore constantly running through the cell-cycle. Scientists successfully guessed that you could effectively impair cancer growth if you inhibited progression through the cell cycle. While many drugs, such as palbociclib and ribociclib, have proven successful in treating cancers this way, there are still some prove unresponsive.

One such cancer is a type of liver cancer called cholangiocarcinoma. It is one of the more common forms of liver cancer and is unresponsive to most chemotherapies with a poor prognosis. Clearly, more work needs to be done to identify a successful therapy option for this cancer, and a team of scientists from the California Pacific Research Institute might have an answer.

The drug dinaciclib is a CDK inhibitor that has shown some promising anti-cancer results in several other studies. Although not FDA approved like palbociclib and others, its ability to target several CDKs with a good safety profile in mouse studies makes it a great candidate for future chemotherapy. In a new study, the team from California investigated to see if dinaciclib could treat cholangiocarcinoma when so many others have failed.

Dinaciclib first came on the team’s radar after a drug screen for cholangiocarcinoma treatment candidates showed it had some effect on cancer. Checking the expression levels of the CDKs dinaciclib targets, it was confirmed that cholangiocarcinoma did indeed have a higher expression of said CDKs. The team decided to test it against the FDA approved palbociclib and found that dinaciclib performed much better against cholangiocarcinoma cells in vitro. A mouse study then showed that in combination with the chemotherapy gemcitabine, the current treatment for cholangiocarcinoma, dinaciclib performed even better in impairing cancer cells’ growth.

This study identified dinaciclib as a promising chemotherapy candidate for cholangiocarcinoma patients. Cholangiocarcinoma has proven unresponsive to many chemotherapies so far. However, dinaciclib combined with gemcitabine is shown to inhibit its growth both in vitro and in vivo significantly. Combined with several other positive studies, make dinaciclib a great novel chemotherapy candidate.

The study concludes, “our data demonstrate, for the first time, the utility of dinaciclib, a well-tolerated cyclin-dependent kinase inhibitor, as a promising selective therapeutic option for treatment of CCA alone or in combination with gemcitabine.”

Sources: Nature Scientific Reports, khanacademymedicine

About the Author
  • Hey everyone! My name is Jasper and, considering I am pretty new here to Labroots, I figured I would introduce myself. I received my bachelor’s from the University of California at Riverside back in 2016. I started off my career a few years ago with a job at a University over in New York, before moving over into the industry. I'm happy to be writing content for Labroots, and I hope you enjoy it!
You May Also Like
SEP 14, 2020
Genetics & Genomics
Why Defects in One Gene Can Lead to Cancer in Kids
SEP 14, 2020
Why Defects in One Gene Can Lead to Cancer in Kids
While they may occur in adults, a rare, aggressive type of brain cancer called atypical teratoid rhabdoid tumors tend to ...
SEP 13, 2020
Cancer
Should we be treating kidney cancer differently?
SEP 13, 2020
Should we be treating kidney cancer differently?
New research published in the journal Clinical Cancer Research is questioning how we treat kidney tumors. According ...
OCT 07, 2020
Cancer
Beyond the eye: improving melanoma detection
OCT 07, 2020
Beyond the eye: improving melanoma detection
Research from UC San Francisco reports that it is possible to use genomic methods to detect skin damage from the sun not ...
OCT 12, 2020
Cancer
Targeting Energy Production in Cells to Fight Leukemia
OCT 12, 2020
Targeting Energy Production in Cells to Fight Leukemia
Much like how a car needs gasoline to run, cells also need a fuel source. Most human cells in the body use oxidative pho ...
OCT 20, 2020
Cancer
Is your physical activity intense enough?
OCT 20, 2020
Is your physical activity intense enough?
Older adults with higher physical activity and lower sitting time have better overall physical and mental health, accord ...
NOV 20, 2020
Cancer
How does tissue geometry influence cancer cellular migration?
NOV 20, 2020
How does tissue geometry influence cancer cellular migration?
A team of researchers led by UC Santa Barbara's Distinguished Professor Denise Montell has recently published new fi ...
Loading Comments...