JUL 06, 2016 4:38 AM PDT

Cancer and Addiction May Share a Common Drug

WRITTEN BY: Xuan Pham
Researchers from the University of London have found that a drug used to combat addiction may also be effective at killing cancer cells. The discovery has wide implications for cancer treatment, given that the drug of interest is naltrexone, a drug widely prescribed for addicts.
 
Drug that helps addicts may help treat cancer too | Image: pixabay.com

Finding new uses for an old drug is a noteworthy endeavor. If the drug is already approved for use in another capacity, researchers can significantly shorten the time it takes before the drug can be prescribed to patients for new applicable uses. Thus the team at St. George’s, University of London, are quite hopeful the discovery will expedite future clinical trials for cancer treatment.
 
In studying the effects of naltrexone on cancer cells, the team observed that the cells stopped growing. They also reported naltrexone altered the cells’ internal working mechanisms, causing certain genes to be turned on at higher intensity. This ultimately led to the cells killing themselves more readily, thus reducing the cancer growth.
 
"Rather than stopping the cancer cells from growing, patients want to be rid of them. We saw that by giving the drug for two days, then withdrawing it, cancer cells would stop cycling and undergo cell death," said Wai Liu, first study author.
 
Through further investigation, the team found that naltrexone selectively affected genes involved in regulating the cell cycle and the immune system. Genes that are involved with programmed cell death were also triggered by naltrexone, implicating a mechanism for the increased deaths of the cancer cells.
 
"We have shown that the genetic fingerprint of naltrexone differs according to the different doses used, which identifies new ways of using it as an anti-cancer treatment,” said Liu. The doses used in the study are much lower than what’s used in treating addiction.
 

 Naltrexone is commonly used to treat alcoholism. And as an opioid antagonist, this drug is also used to treat opioid addiction. At high doses, there’s a risk for liver damage and gastrointestinal problems.
 
And because the drug is already approved and on the market, it becomes that much more attractive. Liu, who has been researching cancer treatments for over two decades, hopes clinical trials will lead to naltrexone use in conjunction with other anticancer treatments. "We have taken a drug that is relatively safe in humans, and reformulated a new use for it; this has only been possible by understanding the dynamics of a drug. How many other drugs can be improved in this way?” asked Liu.

Additional source: MNT
 
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
JUN 07, 2021
Cancer
Inflammatory-rich diet associated with greater risk of developing breast cancer
JUN 07, 2021
Inflammatory-rich diet associated with greater risk of developing breast cancer
A breakthrough study soon to be presented at NUTRITION 2021 LIVE ONLINE later this week reports that women who main ...
JUN 12, 2021
Cancer
Using astronomy to image cancer tumors
JUN 12, 2021
Using astronomy to image cancer tumors
In an interdisciplinary breakthrough, a recent study published in Science describes the development of a new platform, d ...
JUL 12, 2021
Cell & Molecular Biology
A Molecule From the Gut Microbiome May Fight Tumors
JUL 12, 2021
A Molecule From the Gut Microbiome May Fight Tumors
The more we learn abut the gut microbiome, the more it seems that the microorganisms in our gastrointestinal tracts can ...
AUG 18, 2021
Technology
Tracking System Maps How Cancer Cells Evolve, Providing New Treatment Insights
AUG 18, 2021
Tracking System Maps How Cancer Cells Evolve, Providing New Treatment Insights
All cells in a tumor share some genetic similarities, but also have key differences, often hindering effective treatment ...
OCT 14, 2021
Cancer
Mechanism of Resistance to Colorectal Cancer Treatment Uncovered
OCT 14, 2021
Mechanism of Resistance to Colorectal Cancer Treatment Uncovered
Colorectal cancer develops when a series of changes occur across multiple genes.  While researchers have paid signi ...
OCT 26, 2021
Immunology
Two Different Arms, Twice the Cancer-Killing Potential?
OCT 26, 2021
Two Different Arms, Twice the Cancer-Killing Potential?
Our immune system has developed an arsenal of sophisticated molecular weapons to defend us against the continuous barrag ...
Loading Comments...