JAN 19, 2017 6:23 AM PST

Malaria Drug Successfully Shrank Aggressive Brain Tumor

WRITTEN BY: Xuan Pham

Off-label use of an antimalarial drug saved the life of a 26-year-old patient dying of treatment-resistant brain cancer.

Image: CU TuftsThe patient, Lisa Rosendahl, was diagnosed with an aggressive form of brain cancer known as glioblastoma.  "When I was 21 they found a large mass in my brain and I had it resected right away. They tested it for cancer and it came back positive," Lisa said.

"It was a high-risk, aggressive glioblastoma and by the time we started this work, she had already tried everything. For that population, survival rates are dismal,” said Jean Mulcahy-Levy, an oncologist at the Children's Hospital Colorado, and the study’s first author.

Lisa’s doctors initially treated her tumor with Vemurafenib, an inhibitor of BRAF – a gene that promotes cancer growth. However, as expected, the aggressive tumor developed new mutations to subvert the effects of the drug. Consequently, Lisa’s tumor started to grow and threaten her life once again. 

At the time that the drugs stopped working, Lisa’s doctors estimated that she had about 12 months left. “We took all our cousins up to Alaska for a final trip kind of thing. Then they came up with this new combination including chloroquine,” said Greg Rosendahl, Lisa’s father.

Chloroquine is a well-known drug used to prevent and treat malaria. However, Lisa’s physicians realized that a mechanism of this drug could also prove effective against her glioblastoma.

The connection rested upon a specific mutation of the cancer, known as BRAFV600E. This made the cancer inextricably reliant on autophagy for survival. Autophagy is the process whereby the cell breaks down its own components to recycle or to conserve energy. In cancer’s case, autophagy allows it to escape the effects of chemotherapy that would otherwise destroy it. Fortunately, chloroquine works to block this process. In combination with chemotherapy, chloroquine makes the tumor vulnerable to destruction.

Indeed, the off-label combination therapy with chloroquine brought Lisa back from the brink of lost hope. “Miraculously, she had a response to this combination. Four weeks later, she could stand and had improved use of her arms, legs and hands," said Mulcahy-Levy.

As Lisa’s tumor shrank progressively, her quality of life improved dramatically. She’s more mobile now in her new wheelchair, spends more time at the mall, and can enjoy a life unconfined by a looming death status. "She wants to get out and do more. She continues to have what she feels is a good quality of life," Mulcahy-Levy said.

Lisa is not the only patient to have benefited from the antimalarial. "We have treated three patients with the combination and all three have had a clinical benefit. It's really exciting -- sometimes you don't see that kind of response with an experimental treatment. In addition to Lisa, another patient was on the combination two-and-a-half years. She's in college, excelling, and growing into a wonderful young adult, which wouldn't have happened if we hadn't put her on this combination," Mulcahy-Levy reports.

Additional sources: University of Colorado Anschutz Medical Campus

About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
NOV 16, 2019
Cancer
NOV 16, 2019
Understanding H. pylori and gastric cancer
New research published in the journal Gastroenterology offers insight on gastric cancer and the presence of the common bacteria known as H. pylori (Helicob...
NOV 18, 2019
Genetics & Genomics
NOV 18, 2019
Evaluating the Genetic Damage Caused by Cancer Treatments
Now that we know more about the impact of some cancer treatments, they can be applied optimally....
DEC 02, 2019
Cancer
DEC 02, 2019
What patients don't know: the side effects of cancer treatment
If anyone you know has ever had to go through treatment for cancer, or if you yourself have had to, you know that fighting the cancer is only part of the b...
DEC 16, 2019
Cell & Molecular Biology
DEC 16, 2019
When Migrating, Cancer Cells Choose the Path of Least Resistance
Cancer becomes most deadly when it has metastasized - when cancerous cells move away from the site where cancer started growing....
JAN 14, 2020
Cancer
JAN 14, 2020
Could the flu vaccine shrink cancer tumors?
If you’ve been to the doctor recently, you’ve probably been asked if you want a flu shot this year. The flu vaccine is popular because it reduc...
FEB 14, 2020
Immunology
FEB 14, 2020
Rewired natural killer cells show promising results in leukemia patients
Natural killer (NK) cells are a subset of white blood cells that are key players in the innate immune system, orchestrating host-rejection responses agains...
Loading Comments...