MAR 18, 2015 12:41 PM PDT

Tiny Diamonds--A Cancer Cell's Best Friend?

WRITTEN BY: Will Hector
Cancer stem cells often cause tumors to form and are particularly difficult to destroy. They resist chemotherapy, allowing cancer to return.

But scientists say it may be possible to kill those stem cells by attaching a chemo drug to nanodiamonds.
Nanodiamonds found to kill cancer stem cells.
They tested this idea using the commonly used chemo drug Epirubicin, which they attached to nanodiamonds, carbon structures with a diameter of about five nanometers, to develop a nanodiamond-Epirubicin drug delivery complex (EPND).

The researchers found that while both standard Epirubicin as well as EPND were capable of killing normal cancer cells, only EPND was capable of killing chemoresistant cancer stem cells and preventing secondary tumor formation in xenograft models of liver cancer.

The study was published in ACS Nano and led by Edward Chow, assistant professor at the National University of Singapore.

Compared to other approaches, delivery of existing chemotherapy drugs with nanomaterials provide a broader range of protection in a package that is both safer and more effective.

The findings show that delivery of Epirubicin by nanodiamonds resulted in a normally lethal dosage of Epirubicin becoming a safe and effective dosage.

As such, delivery of chemotherapy drugs by nanodiamonds not only enables enhanced killing of chemoresistant cancer stem cells, but may be a useful alternative for patients who cannot tolerate the toxic side effects of standard chemotherapy drugs.

Researchers say this approach is not limited to liver cancer and could potentially treat other cancers driven by resistant stem cells.

Source: National University of Singapore
About the Author
  • Will Hector practices psychotherapy at Heart in Balance Counseling Center in Oakland, California. He has substantial training in Attachment Theory, Hakomi Body-Centered Psychotherapy, Psycho-Physical Therapy, and Formative Psychology. To learn more about his practice, click here: http://www.heartinbalancetherapy.com/will-hector.html
You May Also Like
JAN 28, 2021
Cancer
Research shows 4 in 10 cancer deaths are from cigarette smoking
JAN 28, 2021
Research shows 4 in 10 cancer deaths are from cigarette smoking
No really, put down that cigarette. New research attributes 4 in 10 cancer deaths in the Southern US and Appalachia to c ...
MAR 03, 2021
Cancer
Multiple breast cancer screenings reduce mortality rates
MAR 03, 2021
Multiple breast cancer screenings reduce mortality rates
New research published in the journal Radiology reports on the advantages that multiple breast cancer screenings can hav ...
MAR 09, 2021
Cannabis Sciences
Cannabis Alleviates Neuropathic Pain from Chemotherapy
MAR 09, 2021
Cannabis Alleviates Neuropathic Pain from Chemotherapy
Neuropathic pain from oxaliplatin-based chemotherapy regimens occurs in up to 90% of patients, and continued exposure to ...
MAR 22, 2021
Immunology
Gene Mutation Keeps Tumors "Cold"
MAR 22, 2021
Gene Mutation Keeps Tumors "Cold"
Immunologists have identified a mechanism through which an oncogene mutation shields pancreatic tumors from immune cells ...
APR 19, 2021
Cancer
Understanding why pacreatic cancer metastasizes
APR 19, 2021
Understanding why pacreatic cancer metastasizes
New research published in the journal Gastroenterology reports on the mechanisms of metastatic pancreatic cancer cells, ...
MAY 04, 2021
Clinical & Molecular DX
Vibrating Needles Make for Better Biopsies
MAY 04, 2021
Vibrating Needles Make for Better Biopsies
  To understand what’s going on with a patient, doctors may take a biopsy—a sample of tissue extracted ...
Loading Comments...