APR 05, 2017 01:55 PM PDT

Pancreatic Cancer Risks Linked to Mouth Bacteria

WRITTEN BY: Xuan Pham

The composition of microorganisms in a person’s mouth could affect more than just their breath and dental health. In fact, researchers have linked certain types of bacteria in the mouth to higher pancreatic cancer risks.

Pancreatic cancer is notoriously deadly because the disease progresses silently and diagnosis happens when the cancer has already spread. It’s estimated that of the 53,000 Americans who will be diagnosed with pancreatic cancer this year, almost 79 percent will succumb from the disease.

The human body is inhabited by trillions of bacteria. Specialized collections of these bacteria make up microbiomes in the human body. Mostly famous for their existence in the human gut, these communities of microorganisms have been known to influence health processes like digestion and immune responses.

A team of researchers from NYU Langone’s Laura and Isaac Perlmutter Cancer Center set out to explore the relationship between pancreatic cancer and oral health. They compared the bacterial contents in mouthwash samples from 732 people for 10 years. During this time, 361 people were diagnosed with the disease, while 371 people served as matched controls.

They found a correlation between pancreatic cancer and the presence of two types of bacteria, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, which commonly cause gum disease and periodontitis (gum inflammation).

Compared to people whose samples didn’t have either of the microorganisms, people who had P. gingivalis had a 59 percent increase, and people who had A. actinomycetemcomitans had a 50 percent increase in overall pancreatic cancer risks.

While gum disease and poor oral health have been linked to pancreatic cancer, this study is the first to implicate two microorganisms in the development of this deadly disease. The work was presented at the annual meeting of the American Association for Cancer Research.

"Our study offers the first direct evidence that specific changes in the microbial mix in the mouth - the oral microbiome - represent a likely risk factor for pancreatic cancer along with older age, male gender, smoking, African-American race, and a family history of the disease," said Jiyoung Ahn, epidemiologist and Associate Professor at NYU, and senior study author.

The authors say their study has diagnostic potential for pancreatic cancer, which currently has no routine screening procedures in place. "These bacterial changes in the mouth could potentially show us who is most at risk of developing pancreatic cancer,” said Ahn.

It is important to note that good oral health does not preclude pancreatic cancer, but having a healthy mouth is good for your overall wellness. Good oral hygiene practices include daily brushing with fluoride toothpaste, flossing, and regular dental checkups.

Additional source: Live Science

About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
JUN 19, 2018
Earth & The Environment
JUN 19, 2018
Does Roundup cause cancer?
Monsanto has long been the scary monster lurking in the closet, with its seed-patenting and fertilizer-pushing. Now the first case actually bringing the co...
JUL 24, 2018
Cancer
JUL 24, 2018
FDA Approves New Drug for Refractory/Relapsed AML
A new drug and new drug class have been approved by the FDA for relapsed or refractory AML patients with an IDH1 mutation. The new drug offers options for patients....
JUL 31, 2018
Cancer
JUL 31, 2018
Can Medicine Prevent Cisplatin-associated Hearing Loss for Pediatric Cancer Patients?
Researchers have determined that sodium thiosulfate's antioxidant properties can prevent hearing loss in pediatric cancer patients being treated with Cisplatin....
SEP 15, 2018
Clinical & Molecular DX
SEP 15, 2018
Cancer & Anoikis: A Match Not Made in Heaven
Anoikis have always been intimately entwined with cancer, henceforth the quest to seek how they came to be as such....
OCT 02, 2018
Health & Medicine
OCT 02, 2018
Many Patients Are Unaware of Increased Cancer Risk
Just as recently as a few decades ago, many common health screenings were not readily available. Mammography, for breast cancer detection, wasn't ...
OCT 03, 2018
Cell & Molecular Biology
OCT 03, 2018
Single Cell Modified in CAR T Therapy Causes Deadly Relapse
One cell meant a very different outcome for a patient that was the recipient of a cutting-edge cancer therapy....
Loading Comments...