JAN 22, 2018 2:32 PM PST

New Blood Test for 8 Cancers Works With Mixed Results

WRITTEN BY: Julia Travers

Early diagnosis is hailed as a central factor in determining a cancer patient’s likelihood of experiencing successful treatment and healing. Many types of cancers continue to lack quick, accurate diagnostic methods. A new blood analysis called CancerSEEK can identify eight cancers to varying degrees of success, including five that lack routine screening procedures at this time.

blood test image, credit: medicalnewstoday.com

"This test represents the next step in changing the focus of cancer research from late-stage disease to early disease, which I believe will be critical to reducing cancer deaths in the long term,” study Co-author Dr. Bert Vogelstein of the Johns Hopkins University (JHU) School of Medicine says.

During this study, CancerSEEK was tested on 1005 patients with non-metastatic (cancer that has not spread from its primary site to other locations), clinically-detected cancers of the colorectum, lung, ovary, breast, liver, stomach, pancreas and esophagus. Ovarian, liver, stomach, pancreatic and esophageal cancers do not currently have routines tests for average-risk populations.

When cancer forms, it releases proteins and mutated DNA into the person’s blood. The new test looks for these cancer markers – specifically, 16 gene mutations and eight proteins associated with the eight cancers.

"A novelty of our classification method is that it combines the probability of observing various DNA mutations together with the levels of several proteins in order to make the final call," Co-author Dr. Cristian Tomasetti of JHU says. CancerSEEK identified 70 percent of the cancers. The sensitivity of the test ranged from a high 98 percent for ovarian cancer down to 33 percent for breast cancer. For the five cancers lacking regular screens, the test’s sensitivity fell between 69 and 98 percent. CancerSEEK also zeroed in on the location of the cancers “to a small number of anatomic sites in a median of 83 percent of the patients,” the abstract states.

When 812 cancer-free adults were given the blood evaluation, only seven false-positives were reported. Co-author Dr. Kenneth Kinzler of JHU explained the importance of this specificity in this way: "… false-positive results can subject patients to unnecessary invasive follow-up tests and procedures to confirm the presence of cancer."

According to the study’s authors, early-detected cancers will ideally be treated solely with surgery, but even when this is not possible, other therapies will also be more successful when they can begin earlier on in the cancer’s advancement.

Cancer is a leading cause of death around the globe and more than 1.65 million new cancers were diagnosed in the U.S. in 2017. While cancer in the U.S. is generally declining, it is the JHU researchers’ hope that the evolution and refinement of early detection tests like CancerSEEK can reduce the number of cancer-related deaths worldwide.

The team expresses the need for there to be larger studies at this point into the new blood test and says these studies are already in the works. The research, “Detection and localization of surgically resectable cancers with a multianalyte blood test,” was published in the journal Science in January 2018.

About the Author
  • Julia Travers is a writer, artist and teacher. She frequently covers science, tech, conservation and the arts. She enjoys solutions journalism. Find more of her work at jtravers.journoportfolio.com.
You May Also Like
APR 14, 2021
Clinical & Molecular DX
AI-Powered Imaging System Can Tell If a Patient Is Cancer-Free
APR 14, 2021
AI-Powered Imaging System Can Tell If a Patient Is Cancer-Free
A patient undergoes chemotherapy and radiation for rectal cancer. How do doctors know whether all the malignant tissue h ...
MAY 05, 2021
Immunology
Novel 3D Bio-printed Leukemia Model Shows Potential for Treatment Testing Platform
MAY 05, 2021
Novel 3D Bio-printed Leukemia Model Shows Potential for Treatment Testing Platform
Three-dimensional (3D) printing has become a common technique over the past two decades. Now, the technique has been ado ...
MAY 17, 2021
Cancer
Cells at the center of a tumor are more aggressive and spread faster
MAY 17, 2021
Cells at the center of a tumor are more aggressive and spread faster
New research stemming from a collaboration between researchers from the Francis Crick Institute, Royal Marsden, UCL and ...
MAY 27, 2021
Cancer
Which ovarian cancer patients will be resistant to platinum chemotherapy?
MAY 27, 2021
Which ovarian cancer patients will be resistant to platinum chemotherapy?
Research published in the journal EMBO Molecular Medicine details a novel mechanism that can be used to predict which ep ...
JUN 06, 2021
Cancer
New drug reduces tumor size in lung cancer patients with KRAS gene mutation
JUN 06, 2021
New drug reduces tumor size in lung cancer patients with KRAS gene mutation
The most recent results from the CODEBREAK 100 phase 2 clinical trial support the use of the drug sotorasib to reduce tu ...
JUN 11, 2021
Cell & Molecular Biology
Bad Fat in the Tumor Microenvironment May Disrupt Killer T Cells
JUN 11, 2021
Bad Fat in the Tumor Microenvironment May Disrupt Killer T Cells
The immune system can detect and destroy pathogenic and cancerous cells, but sometimes those dangerous cells can evade t ...
Loading Comments...