MAY 30, 2018 03:39 PM PDT

Cannabis compound shows promise for severe epilepsy

2 2 65

For the first time, a form of medicinal cannabis has been shown to reduce—and even stop—seizures in some children with a severe form of epilepsy.

The children suffer from Dravet syndrome, a severe epilepsy that begins in infancy with drug-resistant seizures and a high mortality rate.

The seizures of five percent of the children stopped after they were treated with cannabidiol, a non-psychoactive form of cannabis. Overall, 43 percent of children with the syndrome had a 50 percent reduction in seizure frequency.

“If you can render any child or adult seizure free, that’s huge.”

Known as CBD, cannabidiol is a natural compound found in cannabis seeds, stalks, and flowers that does not have the psychoactive properties of tetrahydrocannabinol, or THC.

“It’s the first scientific evidence that cannabidiol works,” says Ingrid Scheffer, professor of pediatric neurology at the University of Melbourne. “There have been anecdotal reports in the past, and people with firm beliefs that it works in epilepsy, but this is the first time it’s been proven.”

Something (not emotion) links epilepsy and religion

For the study, published in the New England Journal of Medicine, 120 children and young adults across the US and Europe received cannabidiol or a placebo, in addition to standard anti-epileptic treatment. The research took place as part of the Cannabidiol in Dravet Syndrome Study Group, and was a randomized, double-blind, and placebo-controlled trial.

Researchers measured seizure frequency over a 14-week treatment period. The findings show that the average frequency of convulsive seizures per month decreased from 12.4 to 5.9 among those children on cannabidiol, compared with a decrease from 14.9 to 14.1 among those on the placebo.

“I am delighted that we finally have high-level evidence that cannabidiol is effective for uncontrolled seizures in Dravet syndrome,” Scheffer says.

“If you can render any child or adult seizure free, that’s huge. It could contribute to stopping any further deterioration, or help development in a positive sense.”

Researchers asked caregivers to fill out the Global Impression of Change questionnaire—a seven-category system rating the scale of change in a patient. The results show that the patient’s overall condition improved by at least one category in 62 percent of the cannabidiol group, compared with only 34 percent of the placebo group.

Although the frequency of total seizures of all types was significantly reduced with cannabidiol, there was no significant reduction in non-convulsive seizures. But five percent of patients taking cannabidiol became seizure-free, compared with none of the placebo group.

“Many people who take part in trials like this are desperate to try something new. They’ve exhausted other options,” Scheffer says. “Five percent seizure-free is not 100 percent or 75 percent, but it’s reassuring to see that improvement. For these 5 percent of kids in the trial, it’s huge.

“Sadly this is not a panacea; it’s not going to cure these children. But it does give cause to be optimistic about further research for its use. It also raises a lot of questions, not just in terms of the treatment of epilepsy, but where else it could be applied medicinally. Cannabidiol is likely to be an important addition to our group of anti-epileptic tools.

There is a downside to the findings: side effects were more frequent in the cannabidiol group,  including diarrhea, vomiting, fatigue, decreased appetite, increased body temperature, drowsiness. and abnormal liver-function tests.

Worldwide, it’s estimated that around 1 percent of the population has epilepsy—about 65 million people globally. Dravet syndrome is a rare, catastrophic, lifelong form of epilepsy that begins in infancy. Previously known as Severe Myoclonic Epilepsy of Infancy (SMEI), it affects around 1 in almost 16,000 people.

Current treatment options are limited, and the associated seizures are particularly difficult because they are frequent, unpredictable, life-threatening, and not controlled by many anti-epileptic drugs.

“The next question is whether cannabidiol is effective in other forms of epilepsy,” Scheffer says. “It is great that there are trials already underway of cannabidiol in other groups of patients with epilepsy.”

 

This article was originally published on Futurity.org

About the Author
  • Futurity features the latest discoveries by scientists at top research universities in the US, UK, Canada, Europe, Asia, and Australia. The nonprofit site, which launched in 2009, is supported solely by its university partners (listed below) in an effort to share research news directly with the public.
You May Also Like
FEB 08, 2018
Cannabis Sciences
FEB 08, 2018
Endocannabinoid System Unique Features
The endocannabinoid system is a unique regulatory neurotransmitter system in the body.
MAR 08, 2018
Cannabis Sciences
MAR 08, 2018
Cannabinoids Could Inhibit Tau Hyper-Phosphorylation in Early Alzheimer's Disease
Researchers are looking for possible therapeutic targets in early Alzheimer's Disease to prevent the devastating, irreversible damage of abnormal tau protein induced neurofibrillary tangles.
APR 13, 2018
Cannabis Sciences
APR 13, 2018
What Medical Cannabis Products are Best for You?
There are many ways to ingest cannabis today, but which way is the best for you? If you were to go to a dispensary you would find products to inhale, inges
APR 27, 2018
Cannabis Sciences
APR 27, 2018
Cannabinoid Modulation: How CBD Negates THC
The cannabinoid delta-9 tetrahydrocannabinol (THC) will produce psychoactive effects when consumed.  The outcome is due to the affinity THC has to rec
APR 28, 2018
Cannabis Sciences
APR 28, 2018
The Use of Cannabis in Conjunction with Opioids
In the wake of the opiod epidemic a state has taken a proactive step in the direction to curb the addiction and mortality rate facing this nation.  On
JUN 15, 2018
Cannabis Sciences
JUN 15, 2018
Marijuana chemical may keep HIV patients sharp
Researchers have found that a chemical in marijuana, called tetrahydrocannabinol, or THC, could potentially slow the process of mental decline that affects
Loading Comments...