NOV 29, 2018 12:43 PM PST

How High is Too High? Dosing and CBDs.

WRITTEN BY: Amy Loriaux

A recent study in the journal Pain from researchers out of McGill University may be the first attempt to determine appropriate dosages for cannabidiol (CBD) in treating chronic pain. This is of particular interest because, ever since CBDs have hit the market with claims to help everything from pain to sexual dysfunction, there have been no systematic studies on how much CBD should be ingested to relieve various ailments. Further complicating matters is that CBD is currently classified by the Food and Drug Administration (FDA) as a food supplement and not as a therapeutic. Because of this, CBD companies are actually prohibited to provide dosage information, for in FDA parlance that would be "misbranding", however, since it is considered a food supplement the label is required to provide a "suggesting serving size".

Photo Source: UnSplash.com

As far as THC content goes (there is almost always trace amounts of THC in CBD oil) the legal percentage of THC allowed ranges from 0.03% to 1%, depending on the country. For example, in the European Union (EU), the cultivation of certain cannabis varieties is granted provided the THC content does not exceed 0.2%. Because of the FDA label issues, if you want to get an idea of what "dose" or amount of CBD to ingest, you would have to rely on unauthorized websites and anecdotal evidence. Until CBD oil is seen as a therapeutic instead of a food supplement, this is essentially all the information we have to go on.

The CBD oil industry does provide some dosage recommendations (albeit worded very carefully to not alert authorities). For instance, Highland Pharms, a manufacturer of CBD-based products based out of Washington state, has a page on their website called "How Much CBD Should I Take?" (Serving Size). While they cannot recommend a "dose" per se, they do point out that an average human dose is about 1/mg to 40/mg a day.

Photo Source: A L Loriaux

That is why the report out of McGill is so interesting. It was directed at finding the optimal dose for pain management in rodents. Because this is scientific research performed on animals the FDA has little if any jurisdiction here. What the report found was, at least for pain, a seven-day CBD injection at a dose of 5 mg/kg decreased measures of allodynia (i.e. pain sensitivity) in a rodent model of neuropathic pain. Another interesting finding, which really just adds to the complexity of our endocannabinoid system, is that CBD treatment affected serotonin levels. This effect could ultimately decrease anxiety, which was also seen in the rats. So, in an attempt to not step on the FDA's toes, if one were to use this "magic" dose found in rats to calculate how much CBD a human should be taking, I will leave it for you to do the math. I will end on two words, however: NOT RECOMMENDED!

 

 

Sources: Pain, www.leafly.com, Medical Cannabis and Cannabinoids, European Union Commission, how-much-cbd-should-I-take.comhighlandpharms.com 

About the Author
  • I currently work at a small CRO involved in clinical trial management.
You May Also Like
DEC 20, 2019
Health & Medicine
DEC 20, 2019
Potential Link Between Cannabis Use and Structural Changes to the Heart
Researchers from the Queen Mary University of London used MRI images of more than 3,000 people, 152 of them former or cu ...
FEB 10, 2020
Cannabis Sciences
FEB 10, 2020
Colorado State University Launches Major in Cannabis Sciences
Colorado was one of the first two states in the US, together with Washington, to legalize recreational marijuana in 2012 ...
FEB 25, 2020
Cannabis Sciences
FEB 25, 2020
State to State: Reciprocity for Marijuana Cards Proves Challenging
When a person receives a medical marijuana card, are they good to go, anywhere in the U.S.? No -- it turns out, it can b ...
MAR 20, 2020
Health & Medicine
MAR 20, 2020
THC and Single Joint Linked to Temporary Psychiatric Symptoms
A new analysis of cannabis health risks and benefits reinforces the complexity of this drug, proving that health and ris ...
APR 21, 2020
Cannabis Sciences
APR 21, 2020
Is CBD Effective Against Women's Health Issues?
Products containing cannabidiol (CBD) are increasingly known as a natural and effective way to handle a wide range of wo ...
MAY 16, 2020
Cannabis Sciences
MAY 16, 2020
Body's Own Cannabis Helps Us Forget Traumatic Events
Researchers have found that anandamide, often referred to as the body’s own cannabis, may help us forget traumatic ...
Loading Comments...