NOV 29, 2018 12:43 PM PST

How High is Too High? Dosing and CBDs.

WRITTEN BY: Amy Loriaux

A recent study in the journal Pain from researchers out of McGill University may be the first attempt to determine appropriate dosages for cannabidiol (CBD) in treating chronic pain. This is of particular interest because, ever since CBDs have hit the market with claims to help everything from pain to sexual dysfunction, there have been no systematic studies on how much CBD should be ingested to relieve various ailments. Further complicating matters is that CBD is currently classified by the Food and Drug Administration (FDA) as a food supplement and not as a therapeutic. Because of this, CBD companies are actually prohibited to provide dosage information, for in FDA parlance that would be "misbranding", however, since it is considered a food supplement the label is required to provide a "suggesting serving size".

Photo Source: UnSplash.com

As far as THC content goes (there is almost always trace amounts of THC in CBD oil) the legal percentage of THC allowed ranges from 0.03% to 1%, depending on the country. For example, in the European Union (EU), the cultivation of certain cannabis varieties is granted provided the THC content does not exceed 0.2%. Because of the FDA label issues, if you want to get an idea of what "dose" or amount of CBD to ingest, you would have to rely on unauthorized websites and anecdotal evidence. Until CBD oil is seen as a therapeutic instead of a food supplement, this is essentially all the information we have to go on.

The CBD oil industry does provide some dosage recommendations (albeit worded very carefully to not alert authorities). For instance, Highland Pharms, a manufacturer of CBD-based products based out of Washington state, has a page on their website called "How Much CBD Should I Take?" (Serving Size). While they cannot recommend a "dose" per se, they do point out that an average human dose is about 1/mg to 40/mg a day.

Photo Source: A L Loriaux

That is why the report out of McGill is so interesting. It was directed at finding the optimal dose for pain management in rodents. Because this is scientific research performed on animals the FDA has little if any jurisdiction here. What the report found was, at least for pain, a seven-day CBD injection at a dose of 5 mg/kg decreased measures of allodynia (i.e. pain sensitivity) in a rodent model of neuropathic pain. Another interesting finding, which really just adds to the complexity of our endocannabinoid system, is that CBD treatment affected serotonin levels. This effect could ultimately decrease anxiety, which was also seen in the rats. So, in an attempt to not step on the FDA's toes, if one were to use this "magic" dose found in rats to calculate how much CBD a human should be taking, I will leave it for you to do the math. I will end on two words, however: NOT RECOMMENDED!

 

 

Sources: Pain, www.leafly.com, Medical Cannabis and Cannabinoids, European Union Commission, how-much-cbd-should-I-take.comhighlandpharms.com 

About the Author
  • I currently work at a small CRO involved in clinical trial management.
You May Also Like
MAY 15, 2020
Health & Medicine
Study Recommends 19 As Minimum Legal Age for Recreational Cannabis
MAY 15, 2020
Study Recommends 19 As Minimum Legal Age for Recreational Cannabis
Scientists concluded from a recent study that 19 years of age is the “optimal minimum legal age” for recreat ...
JUL 01, 2020
Health & Medicine
New Venture Will Commercialize Products From Cannabis Research
JUL 01, 2020
New Venture Will Commercialize Products From Cannabis Research
Though the history of cannabis dates back at least three thousand years, the workings of the endocannabinoid system-the ...
JUL 21, 2020
Cannabis Sciences
Teenage Cannabis Use Affects Girls More than Boys
JUL 21, 2020
Teenage Cannabis Use Affects Girls More than Boys
Researchers from the University of Montreal, Canada, have found that cannabis affects the working memory of girls at hig ...
JUL 23, 2020
Cannabis Sciences
Lab Tests Show Levels of THC Can Rise in CBD Oil During Storage
JUL 23, 2020
Lab Tests Show Levels of THC Can Rise in CBD Oil During Storage
To be federally legal in all states CBD (cannabidiol) oil must contain less than 0.3 percent of the psychoactive ingredi ...
JUL 29, 2020
Cannabis Sciences
CBD Tablets Help People Quit Cannabis
JUL 29, 2020
CBD Tablets Help People Quit Cannabis
Cannabis use disorder is essentially cannabis addiction. Although research suggests that it affects 9% of peop ...
AUG 04, 2020
Cannabis Sciences
Nanotechnology Makes Medicinal Cannabis More Effective
AUG 04, 2020
Nanotechnology Makes Medicinal Cannabis More Effective
It seems that cannabis can treat everything- from chronic pain to acne and maybe even cancer. But as cannabinoids are kn ...
Loading Comments...