AUG 06, 2020 5:16 PM PDT

Identifying a Prognostic Biomarker for Neurological Deterioration After a Stroke

WRITTEN BY: Jasper Cantrell

Strokes are life-changing events that can cause a myriad of issues even after it is over. Plenty of tests, such as the national institute of health stroke scale (NIHSS), can gauge the severity of a stroke and predict the severity of the after-effects. Most of these tests use clinical indicators to generate prognosis, but no test utilizes biomarkers.

A team from the Seoul National University College of Medicine wanted to remedy that using the protein serum cardiac troponin 1. Troponin 1 is a protein involved in muscle contraction in the heart and is already a prognostic biomarker for heart attacks. The team specifically wanted to know if it could predict early neurological deterioration after a stroke.

Early neurological deterioration is when a patient experiences damage to neurological function after a stroke. To test this, they pulled data from over a thousand patients and examined several clinical and biological indicators, including troponin 1. Overall, they found that early neurological deterioration was associated with age, not using anti-coagulants, a high NIHSS score, and increased troponin levels. The NIHSS score is usually a good indicator of a good or poor prognosis after stroke. Further analysis showed that troponin levels and NIHSS scores were positively associated, giving more support for troponin 1 as a prognostic biomarker.

The study found that if troponin 1 levels were above a certain threshold in the blood (0.03ng/ml), there was an increased risk of neurological deterioration, while troponin levels below the threshold predicted a much lower risk. This observation could even predict neurological deterioration at low NIHSS scores, where NIHSS had a more favorable prognosis. It did not have enough evidence to be used as a solo marker but has the potential to be used in combination with clinical indicators already in place.

Biomarkers have been a significant area of research in recent years, with many useful biomarkers for cancer and other diseases identified every year. Cardiovascular biomarkers have been more of a challenge to identify, but troponin 1 has shown itself to be a great indicator of prognosis after a stroke or heart attack. This study showed troponin 1 could even be used to predict neurological damage, which could help patients and doctors get ahead of the problem faster than with clinical indicators alone.

The study concludes, “even slight increases in cTnI should be cautiously interpreted and the patients need close observation. However, our insights must be validated with further large, prospective studies.”

Sources: Nature Scientific Reports, Duke Clinical Research Institute

About the Author
  • Hey everyone! My name is Jasper and, considering I am pretty new here to Labroots, I figured I would introduce myself. I received my bachelor’s from the University of California at Riverside back in 2016. I started off my career a few years ago with a job at a University over in New York, before moving over into the industry. I'm happy to be writing content for Labroots, and I hope you enjoy it!
You May Also Like
SEP 10, 2020
Cardiology
Many Doctors Have Used the Wrong Criteria to Diagnose Hypertension
SEP 10, 2020
Many Doctors Have Used the Wrong Criteria to Diagnose Hypertension
A recent survey has shown that most health care professionals may not be using the current information to screen for and ...
NOV 12, 2020
Cardiology
Creating a Mouse Model to Test RBM20 Dependent Dilated Cardiomyopathy
NOV 12, 2020
Creating a Mouse Model to Test RBM20 Dependent Dilated Cardiomyopathy
Cardiovascular disease is something that, in most cases, is within our ability to control. A healthy diet and active lif ...
DEC 13, 2020
Cardiology
Potential Treatment for Common Cause of Heart Disease is ID'ed
DEC 13, 2020
Potential Treatment for Common Cause of Heart Disease is ID'ed
The most common cause of heart disease in elderly people is calcific aortic valve disease, in which calcium builds up in ...
DEC 24, 2020
Cardiology
The Detrimental Health Impact of Ultra-Processed Foods
DEC 24, 2020
The Detrimental Health Impact of Ultra-Processed Foods
Prepared and highly processed foods have become very common, and they've been linked to negative health effects like obe ...
FEB 01, 2021
Cardiology
Improving the Lives of Spinal Cord Injury Patients
FEB 01, 2021
Improving the Lives of Spinal Cord Injury Patients
Spinal cord injury patients obviously have to deal with the loss of function, but another, less obvious problem many of ...
APR 06, 2021
Cardiology
In 2020, Deaths in the US Were Over 20% Higher Than Typical Years
APR 06, 2021
In 2020, Deaths in the US Were Over 20% Higher Than Typical Years
Researchers have begun to analyze the impact of the pandemic, and their work has shown that long COVID-19 surges in the ...
Loading Comments...