SEP 29, 2020 10:05 AM PDT

Improving Acute Myocardial Ischemia Treatment with Nitro Fatty Acids

WRITTEN BY: Jasper Cantrell

Acute myocardial ischemia occurs when blood flow is restricted in the heart. This usually leads to cardiovascular issues, but treatments have advanced quite far. However, one thing that still plagues patients experiencing acute myocardial ischemia is the development of ventricular tachycardia.

Ventricular tachycardia is when your heart consistently beats above 100 beats per minute. This causes strain on your heart and your blood vessels, which can lead to damage. Acute myocardial ischemia patients who develop ventricular tachycardia have a four times higher risk of death than those who don’t. Therefore, it is crucial to identify tachycardia indicators to catch it early, and possibly even treat it.

A team out of the University of Cologne in Germany decided to tackle the problem using nitro-oleic acid. Nitro-oleic acid is a molecule your body produces naturally and is known to act as an anti-inflammatory that can treat several cardiovascular disorders. Their new study tested whether nitro-oleic acid could be used against ventricular tachycardia.

The team used a mouse model to see if nitro-oleic acid treatment before inducing ventricular tachycardia could prevent tachycardia. Pretreated mice did not develop ventricular tachycardia as frequently as those who were not.

Calcium signaling is an essential component of proper muscle contraction, so the team investigated if nitro-oleic acid affected the system. They induced dysfunction to calcium signaling in cardiac cells and found the nitro-oleic acid could recover normal signaling. Further investigation pointed to nitro-oleic acid seemed to inhibit a critical calcium regulator CaMKII, which stabilized calcium signaling.

This study showed that nitro-oleic acid, a molecule already known to treat several cardiovascular diseases, can prevent the development of ventricular tachycardia in mice. The team isolated the mechanism of action to CaMKII inhibition, which prevented abnormal calcium signaling and stabilized heart contractions. The findings still need to be confirmed in a more extensive study before moving on to human testing.

The study concluded, “we show for the first time that, by inhibiting CaMKII, NO2-OA modulates a critical pathway of electrical remodeling following AMI and thus has potential as a pre-emptive anti-arrhythmic strategy for patients at risk for developing AMI.”

Sources: Nature Scientific Reports, khanacademymedicine

About the Author
  • Hey everyone! My name is Jasper and, considering I am pretty new here to Labroots, I figured I would introduce myself. I received my bachelor’s from the University of California at Riverside back in 2016. I started off my career a few years ago with a job at a University over in New York, before moving over into the industry. I'm happy to be writing content for Labroots, and I hope you enjoy it!
You May Also Like
MAY 25, 2020
Drug Discovery & Development
Hydrochloroquine Increases Risk of Death by COVID-19
MAY 25, 2020
Hydrochloroquine Increases Risk of Death by COVID-19
Researchers have found that hydroxychloroquine is not an effective treatment for COVID-19. Their study found that it lea ...
AUG 01, 2020
Cardiology
A Breakthrough in Using Human Cells to 3D Print a Heart Pump
AUG 01, 2020
A Breakthrough in Using Human Cells to 3D Print a Heart Pump
This study has also demonstrated that there is a way to print heart muscle cells that causes them to organize and work i ...
SEP 17, 2020
Cardiology
Can Grape Polyphenol Extracts prevent Cardiotoxicity?
SEP 17, 2020
Can Grape Polyphenol Extracts prevent Cardiotoxicity?
One of the biggest issues with chemotherapy treatments is their inherent toxicities. Most chemotherapy drugs are toxic t ...
OCT 06, 2020
Cardiology
A New Heart Drug Taken from a Yellow Dye
OCT 06, 2020
A New Heart Drug Taken from a Yellow Dye
Cardiovascular disease is an ever-present issue in the modern world.  One of the most unfortunate cardiovascular ev ...
OCT 12, 2020
Cardiology
Pig Hearts Might be Used in Human Transplants by the End of 2021
OCT 12, 2020
Pig Hearts Might be Used in Human Transplants by the End of 2021
A major problem in the transplant field is a lack of healthy donor organs. For many years, scientists in the field of re ...
OCT 20, 2020
Cardiology
Investigating a New Method in Heart Repair
OCT 20, 2020
Investigating a New Method in Heart Repair
Cardiovascular disease is a widespread issue that affects millions across the world. One of the most common of these dis ...
Loading Comments...